•Education and Experience
1996-Present State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Professor
2004-2005 University of Bielefeld, Visiting Professor
1992-1995 University of Queensland（Advisor: W. Kitching）,Postdoc.
1989-1992 State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Associate Professor
1986-1989 Lanzhou University, Ph.D.
1985-1986 West China School of Pharmacy, Sichuan University, Teaching Assistant
1982-1985 Lanzhou University, M.D.
1978-1982 Lanzhou University, B.S.
•Honors and Rewards
2022 The Chiral Chemistry Award of Chinese Chemical Society
2016 China's State Natural Science Award (Second class, rank No.1)
2015 Natural Science Award of Ministry of Education（First class, rank No.1）
2015 Weishan Natural Product Synthesis Award of Chinese Chemical Society
2012 National Outstanding Scientists and Technologists
2006 Natural Science Award of Gansu Province
2005 Distinguished Scientific Achievement Award of Eli Lilly and Company
2004 Cheungkong Scholars Distinguished Professor
2002 Science and Technology Progress Award of Gansu Province (First class )
2001 Organic Chemistry Innovation Group" Fund of National Natural Science Foundation of China （With Three Consecutive Grants ）
2000 Outstanding Young Scholar Award of Qiushi Science & Technologies Foundation
2000 National Science Fund for Distinguished Young Scholars
1996 Millions of Talents Project
1993 Young Chemist Award of Chinese Chemical Society
•Research Topics
total syntheses of bioactive natural products; the design and syntheses of spiral pyrrolidine-derived organocatalysts and ligands and their applications in catalytic asymmetric reaction development
•Selected Publications
1. An Effective and Versatile Strategy for the Synthesis of Structurally Diverse Heteroarylsilanes via Ir(III)-Catalyzed C-H Silylation. Zhi-Bo Yan, Meng Peng, Qi-Long Chen, Ka Lu, Yong-Qiang Tu*, Kun-Long Dai, Fu-Min Zhang, Xiao-Ming Zhang, Chem. Sci. 2021, 12, 9748-9753.
2. Enantioselective Construction of 2-Aryl-2,3-dihydrobenzofuran Scaffolds Using Cu/SPDO-Catalyzed [3 + 2] Cycloaddition. Ze-Ran Jing, Dong-Dong Liang, Jin-Miao Tian*, Fu-Min Zhang*, Yong-Qiang Tu*, Org. Lett. 2021, 23, 1258-1262.
3. Remote Asymmetric Conjugate Addition Catalyzed by a Bifunctional Spiro-Pyrrolidine-Derived Thiourea Catalyst. Ming-Hui Xu, Yong-Hai Yuan, Dong-Dong Liang, Xiao-Ming Zhang*, Fu-Min Zhang, Yong-Qiang Tu*, Ai-Jun Ma, Kun Zhang, Jin-Bao Peng, Org. Chem. Front. 2021, 8, 3292-3297.
4. Collective Total Synthesis of Aspidofractinine Alkaloids through the Development of a Bischler-Napieralski/Semipinacol Rearrangement Reaction. Shuanghu Wang, Ruiqi Si, Qingbo Zhuang, Xiang Guo, Tian Ke, Xiaoming Zhang*, Fumin Zhang*, and Yongqiang Tu*. Angew. Chem. Int. Ed. 2020, 59, 21954-21958.
5. Enantioselective Catalytic Aldehyde α-Alkylation/Semipinacol Rearrangement: Construction of α-Quaternary-δ-Carbonyl Cycloketones and Total Synthesis of (+)-Cerapicol. Jie Yang, Xiaoming Zhang*, Fumin Zhang, Shaohua Wang, Yongqiang Tu*, Zhen Li, Xichao Wang, and Hong Wang. Angew. Chem. Int. Ed. 2020, 59, 8471-8475.
6. Facile Access to Diverse All-Carbon Quaternary Center Containing Spirobicycles by Exploring a Tandem Castro-Stephens Coupling/Acyloxy Shift/ Cyclization/Semipinacol Rearrangement Sequence. Ye Zhang, Tianlu Zheng, Fu Cheng, Kunlong Dai, Kun Zhang, Aijun Ma, Fumin Zhang, Xiaoming Zhang, Shaohua Wang*, and Yongqiang Tu*. Chem. Sci. 2020, 11, 3878-3884.
7. Development of Unique Dianionic Ir(III) CCC Pincer Complexes with a Favourable Spirocyclic NHC Framework. Zhibo Yan, Kunlong Dai, Binmiao Yang, Zihao Li, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, Meng Peng, Qilong Chen and Zeran Jing. Sci. China Chem. 2020, 63, 1761-1766.
8. Atroposelective Synthesis of Axially Chiral 3‑Arylindoles by Copper-Catalyzed Asymmetric Cross-Coupling of Indoles with Quinones and Naphthoquinones. Chaochao Xi, Xiaojing Zhao, Jinmiao Tian*, Zhimin Chen*, Kun Zhang, Fumin Zhang, Yongqiang Tu*, and Jiawei Dong. Org. Lett. 2020, 22, 4995-5000.
9. Construction of Polyfunctionalized 6-5-5 Fused Tricyclic Carbocycles via One-Pot Sequential Semipinacol Rearrangement/Michael Addition/Henry Reaction. Fuping Zhu, Xiang Guo, Fumin Zhang*, Xiaoming Zhang, Hongwang and Yongqiang Tu*. Org. Lett. 2020, 22, 2076-2080.
10. Exploration of a KI-Catalyzed Oxidation System for Direct Construction of Bispyrrolidino[2,3-b]indolines and the Total Synthesis of (+)-WIN 64821. Sikai Chen, Jusong Yang, Kunlong Dai, Fumin Zhang*, Xiaoming Zhang*, and Yongqiang Tu*. Chem. Commun. 2020, 56, 121-124.
11. Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II. Yonghai Yuan, Xue Han, Fuping Zhu, Jinmiao Tian, Fumin Zhang, Xiaomin Zhang, Yongqiang Tu*, Shaohua Wang, and Xiang Guo, Nat. Commun., 2019, 10, 3394.
12. Copper‐Complex‐Catalyzed Asymmetric Aerobic Oxidative Cross‐Coupling of 2‐Naphthols: Enantioselective Synthesis of 3,3′‐Substituted C1‐Symmetric BINOLs. Jinmiao Tian, Aifang Wang, Jusong Yang, Xiaojin Zhao, Yongqiang Tu*, Shuyu Zhang, and Zhimin Chen. Angew. Chem. Int. Ed., 2019, 58, 11023.
13. Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine. Qing Zhang, Fumin Zhang,* Changsheng Zhang, Sizhan Liu, Jinmiao Tian, Shaohua Wang Xiaomin Zhang, and Yongqiang Tu*, Nat. Commun., 2019, 10, 2507.
14. A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] skeleton. Lin Liu, Linsheng Lei, Zongsong Zhan, Sizhan Liu, Yuxiao Wang, YongqiangTu*, Fumin Zhang, Xiaoming Zhang, Aijun Ma, and Shaohua Wang*. Chem. Commun. 2019, 55, 3789.
15. Copper-catalyzed highly diastereoselective cross-dehydrogenative coupling between 8-hydroxyisochromanes and 1,3-dicarbonyl compounds. Zhen Zhang, Yongqiang Tu*, Xiaoming Zhang, Fumin Zhang, and Shaohua Wang. Org. Chem. Front. 2019, 6, 2275.
16. Organo-Cation Catalyzed Asymmetric Homo/Heterodialkylation of Bisoxindoles: Construction of Vicinal All-Carbon Quaternary Stereocenters and Total Synthesis of (−)-Chimonanthidine. Sikai Chen, Wenqiang Ma, Zhibo Yan, Fumin Zhang, Shaohua Wang, Yongqiang Tu*, Xiaoming Zhang, and Jinmiao Tian; J. Am. Chem. Soc. 2018, 140, 10099.
17. Electrophilic Trifluoromethylthiolation/Semipinacol Rearrangement: Preparation of β‑SCF3 Carbonyl Compounds with α‑Quaternary Carbon Center. Chaochao Xi, Zhimin Chen, Shuyu Zhang, and Yongqiang Tu*. Org. Lett. 2018, 20, 4227.
18. A catalytic allylic cation-induced intermolecular allylation-semipinacol rearrangement. Minghui Xu, Kunlong Dai, Yongqiang Tu*, Xiaoming Zhang, Fumin Zhang, and Shaohua Wang. Chem. Commun., 2018, 54, 7685.
19. Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Lin Liu, Hailong Cheng, Wenqiang Ma, Sihua Hou, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, and Shaohua Wang. Chem. Commun. 2018, 54, 196.
20. Recent Progress in the Isolation, Bioactivity, Biosynthesis, and Total Syntheses of Natural Spiroketals. Zhang F.-M., Zhang S.-Y.; Tu, Y.-Q.* Nat. Prod. Rep. 2018, 35, 75-104.
21. Recent Applications of the 1,2-Carbon Atom Migration Strategy in Complex Natural Product Total Synthesis. Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H. Chem. Soc. Rev., 2017, 46, 2272-2305.
22. Total Syntheses of the Tetracyclic Cyclopiane Diterpenes Conidiogenone, Conidiogenol, and Conidiogenone B. Hou, S.-H.; Tu, Y.-Q.*; Wang, S.-H.; Xi, C.-C.; Zhang, F.-M.; Wang, S.-H.; Li, Y.-T.; Liu, L. Angew. Chem. Int. Ed. 2016, 55, 4456-4460.
23. Radical Aryl Migration Reactions and Synthetic Applications. Chen, Z.-M.; Zhang, X.-M.; Tu, Y.-Q.* Chem. Soc. Rev. 2015, 44, 5220-5245.
24. Tandem C-H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (-)-brussonol and (-)-przewalskine E. Jiao, Z.-W.; Tu, Y.-Q.*; Zhang, Q.; Liu, W.-X.; Zhang, S.-Y.; Wang, S.-H.; Zhang, F.-M.; Jiang, S. Nat. Commun. 2015, 6, 7332.
25. Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4] nonane-1, 6-diones. Yang, B.-M.; Cai, P.-J.; Tu, Y.-Q.*; Yu, Z.-X.; Chen, Z.-M.; Wang, S.-H.; Wang, S.-H.; Zhang, F.-M. J. Am. Chem. Soc. 2015, 137, 8344-8347.
26. Divergent and Efficient Syntheses of the Lycopodium Alkaloids (-)-Lycojaponicumin C, (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Hou, S. H.; Tu, Y.-Q.*; Liu, L.; Zhang, F. M.; Wang, S. H.; Zhang, X. M. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.
27. Copper-Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols. Chen, Z. M.; Bai, W.; Wang, S. H.; Yang, B. M.; Tu, Y.-Q.*; Zhang, F. M. Angew. Chem. Int. Ed. 2013, 52, 9781-9785.
28. Total Synthesis of the Nominal Didemnaketal A. Zhang, F. M.; Peng, L.; Li, H.; Ma, A. J.; Peng, J. B.; Guo, J. J.; Yang, D.; Hou, S. H.; Tu, Y.-Q.*; Kitching, W. Angew. Chem. Int. Ed. 2012, 51, 10846-10850.
29. Organocatalytic Asymmetric Direct Csp3-H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers. Jiao, Z. W.; Zhang, S. Y.; He, C.; Tu, Y.-Q.*; Wang, S. H.; Zhang, F. M.; Zhang, Y. Q.; Li, H. Angew. Chem. Int. Ed. 2012, 51, 8811-8815.
30. Total Synthesis of (+/-)-Alopecuridine and Its Biomimetic Transformation into (+/-)-Sieboldine A. Zhang, X. M.; Tu, Y.-Q.*; Zhang, F. M.; Shao, H.; Meng, X. Angew. 21. Direct Sp3 alpha-C-H Activation and Functionalization of Alcohol and Ether. Zhang, S. Y.; Zhang, F. M.; Tu, Y.-Q.*Chem. Soc. Rev. 2011, 40, 1937-1949.
31. Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy. Wang, B. M.; Tu, Y.-Q.* Acc. Chem. Res. 2011, 44, 1207-1222.
32. Semipinacol Rearrangement in Natural Product Synthesis. Song, Z. L.; Fan, C. A.; Tu, Y.-Q.* Chem. Rev. 2011, 111, 7523-7556.
33. Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral alpha-Oxa-Quaternary beta-Haloketones. Chen, Z. M.; Zhang, Q. W.; Chen, Z. H.; Li, H.; Tu, Y.-Q.*; Zhang, F. M.; Tian, J. M. J. Am. Chem. Soc. 2011, 133, 8818-8821.
34. Iron-Catalyzed C(sp(3))-C(sp(3)) Bond Formation through C(sp(3))-H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes. Zhang, S. Y.; Tu, Y.-Q.*; Fan, C. A.; Zhang, F. M.; Shi, L. Angew. Chem. Int. Ed. 2009, 48, 8761-8764.
35. Bronsted Acid Catalyzed Enantioselective Semipinacol Rearrangement for the Synthesis of Chiral Spiroethers. Zhang, Q. W.; Fan, C. A.; Zhang, H. J.; Tu, Y.-Q.*; Zhao, Y. M.; Gu, P.; Chen, Z. M. Angew. Chem. Int. Ed. 2009, 48, 8572-8575.
36. Organocatalytic Asymmetric Vinylogous alpha-Ketol Rearrangement: Enantioselective Construction of Chiral All-Carbon Quaternary Stereocenters in Spirocyclic Diketones via Semipinacol-Type 1, 2-Carbon Migration. Zhang, E.; Fan, C. A.; Tu, Y.-Q.*; Zhang, F. M.; Song, Y. L. J. Am. Chem. Soc. 2009, 131, 14626-14627.
37. A Reaction for sp(3)-sp(3) C-C Bond Formation via Cooperation of Lewis Acid-Promoted/Rh-Catalyzed C-H Bond Activation. Shi, L.; Tu, Y.-Q.*; Wang, M.; Zhang, F. M.; Fan, C. A.; Zhao, Y. M.; Xia, W. J. J. Am. Chem. Soc. 2005, 127, 10836-10837.
38. A Tandem Semipinacol Rearrangement/Alkylation of alpha-Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1, 3-Diols. Hu, X. D.; Fan, C. A.; Zhang, F. M.; Tu, Y.-Q.* Angew. Chem. Int. Ed. 2004, 43, 1702-1705.
39. Samarium-Catalyzed Tandem Semipinacol Rearrangement/Tishchenko Reaction of alpha-Hydroxy Epoxides: A Novel Approach to Highly Stereoselective Construction of 2-Quaternary 1, 3-Diol Units. Fan, C. A.; Wang, B. M.; Tu, Y.-Q.*; Song, Z. L. Angew. Chem. Int. Ed. 2001, 40, 3877-3880.
40. Stereoselective Reductive Rearrangement of alpha-Hydroxy Epoxides: A New Method for Synthesis of 1, 3-Diols. Tu, Y.-Q.*; Sun, L. D.; Wang, P. Z. J. Org. Chem. 1999, 64, 629-633.
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