Longlong Tian

PhD、Professor

E-Mail：

tianll12@lzu.edu.cn

· Research Topics

Radionuclides recognition；Radiopharmaceutical；

Precise recognition of radionuclides is the foundation for their efficient acquisition and safe application. Based on the physical and chemical properties of metal radionuclides, we have developed precise identification strategies for radionuclides at multiple scales such as biomacromolecules (DNA, protein) and nanomaterials, and elucidated the coupling modes and effects between nanomaterials and radionuclides.

Radiopharmaceuticals are a class of drugs that contain radionuclides (emiting high-energy radiation, such as gamma, alpha or beta particles), which can be used for both diagnostic and therapeutic purposes in nuclear medicine. Radiopharmaceuticals are a crucial component of nuclear medicine and play a significant role in the fight against cancer.

· Publications

1. A Radioluminescent Metal-Organic Framework for Monitoring 225Ac in Vivo. Yugang Zhang, Feize Li, Zhencun Cui, Kai Li, Jingwen Guan, Longlong Tian*, Yaxing Wang*, Ning Liu, Wangsuo Wu, Zhifang Chai, and Shuao Wang*.  Journal of the American Chemical Society 2023, 145, 27, 14679-14685.

2. 32P-labeled Two-Dimensional ZnFe(CN)5NO with Cerenkov Luminescence Stimulated NO Release for Enhanced Combinational Radioisotope-Immunotherapy. Longlong Tian, Yaxing Wang, Lele Sun, Jun Xu, Yu Cao, Kai Yang, Shuao Wang and Zhuang Liu*.  Matter 2019, 1, 1061-1076.

3. Constructing Two-Dimensional (2D) Heterostructure Channels with Engineered Biomembrane and Graphene for Precise Scandium Sieving. Jing Liang, Xin Zhang, Haidong Li, Chuanxi Wen, Longlong Tian*, Ximeng Chen*, and Zhan Li*.  Advanced Materials 2024, 202404629.

4. Calcium Bisphosphonate Nanoparticles with Chelator-Free Radiolabeling to Deplete Tumor-Associated Macrophages for Enhanced Cancer Radioisotope Therapy. Longlong Tian, Xuan Yi, Zhiliang Dong, Jun Xu, Liang Chao, Yu Cao, Yaxing Wang, Kai Yang* and Zhuang Liu*.  ACS Nano 2018, 12, 11541-11551.

5. Coordination Polymers Integrating Metalloimmunology with Immune Modulation to Elicit Robust Cancer Immunology. Longlong Tian, Yujie Zhu, Jun Xu, Ming Shao, Wenjun Zhu, Zhisheng, Xiao, Qian Chen, Zhuang Liu*.  CCS Chemistry 2020, 2, 2629-2642.

6. Designing biomimetic two-dimensional channels for uranium separation from seawater. Wenbin Liang, Xin Zhang, Liqin Wang, Chuanxi Wen, Longlong Tian*, Zhan Li*, Ximeng Chen and Wangsuo Wu.  Chemical Science 2024, 10.1039/D4SC02801E.

7. Imageable Brachytherapy with Chelator-Free Radiolabeling Hydrogel. Zhencun Cui, Liqin Wang, Wei Liu, Dan Xu, Taofeng Zhang, Baoliang Ma, Kai Zhang, Lingyan Yuan, Zhitong Bing, Jiangyan Liu*, Bin Liu*, Wangsuo Wu, and Longlong Tian*.  Advanced Healthcare Materials 2024, 202401438.

8. Epigenetic Platinum Complexes Breaking the “Eat Me/Don’t Eat Me” Balance for Enhanced Cancer Chemoimmunotherapy. Longlong Tian, Ming Shao, Yimou Gong, Ting Wei, Yujie Zhu, Yu Chao, and Zhuang Liu*.  Bioconjugate Chemistry 2022, 33, 343-352. (ACS Editors’ Choice)

9. Albumin-Binding Lipid-Aptamer Conjugates for Cancer Immunoimaging and Immunotherapy. Longlong Tian, Ming Shao, Yimou Gong, Yu Chao, Ting Wei, Kai Yang, Qian Chen* and Zhuang Liu*.  Science China Chemistry 2022, 65, 574-583.

10. ATP-Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity. Lele Sun#, Fengyun Shen#, Longlong Tian#, Huiquan Tao, Zijian Xiong, Jun Xu, Zhuang Liu*.  Advanced Materials 2021, 2007910.

11. Albumin-Templated Manganese Dioxide Nanoparticles for Enhanced Radioisotope Therapy. Longlong Tian#, Qian Chen#, Xuan Yi, Jiawen Chen, Chao Liang, Yu Chao, Kai Yang*, Zhuang Liu*.  Small 2017, 13, 1700640.

12. Radionuclide I-131 Labeled Albumin-Paclitaxel Nanoparticles for Synergistic Combined Chemo-radioisotope Therapy of Cancer. Longlong Tian#, Qian Chen#, Xuan Yi, Guanglin Wang, Jie Chen, Ping Ning, Kai Yang*, Zhuang Liu*.  Theranostics 2017, 7, 614-623.