•Education and Experience
2017-Present College of Chemistry and Chemical Engineering, Lanzhou University, State Key
Key Laboratory of Applied Organic Chemistry, Professor
2014-2016 College of Mechanics and Materials, Hohai University, Professor
2013-2016 Nanjing Genome Biotechnology Co., Ltd., CEO
2010-2013 GenScript Inc., VP
2007-2009 GenScript Inc., R&D Director
2006-2007 GenScript Inc., Protein Dept. Director
2004-2006 GenScript Inc., Principle Scientist
1999-2004 GenScript Inc., Senior Scientist
1998-1999 Columbia University (Advisor: David J. Volsky)，Postdoc
1993-1998 Rutgers University (Advisor: Tariq M. Rana)，Ph.D.
1987-1990 Lanzhou University, M.S.
1982-1987 Lanzhou University, B.Sc.
•Honors and Awards
2011 “business startups and innovation” award from Jiangsu Province
2009 “Innovation Prize” from GenScript Inc.
1997 “Stanley Mandeles” Research Award from Rutgers University
•Rsearch Topics
1. High-throughput screening (HTS)： identify active compounds from a compound library and active peptides from a peptide library;
2. Synthetic Biology: synthesize de nova genes using PCR and cloning technology;
3. Proteins and peptides: design, express, purify and characterize peptides, cyclic peptides and proteins;
4. Peptide drug discovery: identify active peptides from a cyclic peptide library and then optimize the peptide sequences.
•Publications
1.“Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: Potential role in neuropathogenesis”. Zhuying Wang, Gusta Trillo Pazos, Seon Young Kim, Mario Canki, Susan Morgello, Leroy R. Sharer, Harris A. Gelbard, Zaozhong Su, Dongchul Kang, Andrew I. Brooks, Paul B. Fisher, and David J. Volsky*. J. of NeuroVirology 2004, 10 (Suppl.1), 1-8.
2.“Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp 120”. Zhuying Wang, Olga Pekarskaya, Meryem Bencheikh, Wei Chao, Harris A. Gelbard, Anuja Ghorpade, Jeffrey D. Rothstein, and David J. Volsky*. Virology 2003, 312(1), 60-73.
3.“Probing Tat Peptide-TAR Interactions by Psoralen Photo-Cross-Linking". Zhuying Wang, Kavita Shah and Tariq M. Rana*. Biochemistry 2001, 40, 6458-6464.
4.“Probing RNA-Protein Interaction by Psoralen photocrosslinking". Zhuying Wang and Tariq M. Rana*. Methods Mol. Biol. 1999, 118, 49-62.
5.“Proximity of a Tat peptide to the HIV-1 TAR RNA loop region determined by Site-Specific Photo-Cross-linking”. Zhuying Wang and Tariq M. Rana*. Bioconjugate Chemistry 1999, 10, 512-519.
6.“RNA-Protein Interactions in the Tat-TAR Complex Determined by Site-Specific Photocrosslinking". Zhuying Wang and Tariq M. Rana*. Biochemistry 1998, 37, 4235-4243.
7.“DNA Damage-Dependent Transcriptional Arrest and Termination of RNA Polymerase II Elongation Complexes in DNA Template Containing HIV-1 Promoter”. Zhuying Wang and Tariq M. Rana*. Proc. Natl. Acad. Sci. USA, 1997, 9, 6688-6693.
8.“RNA Conformation in Tat-TAR Complex Determined by Site-Specific Photocrosslinking”. Zhuying Wang and Tariq M. Rana*. Biochemistry 1996, 35, 6491-6499.
9.“Protein Orientation in Tat-TAR Complex Determined by Psoralen Photocrosslinking”. Zhuying Wang and Tariq M. Rana*. J. Biol. Chem. 1996, 271, 16995-16998.
10.“Chemical Conversion of a TAR RNA-Binding Fragment of HIV-1 Tat Protein into a Site-Specific Crosslinking Agent”. Zhuying Wang, Kavita Shah and Tariq M. Rana*, J. Amer. Chem. Soc., 1995, 117, 5438-5444.
•Patents
1.“Gel electrophoresis device for loading large sample”. Patent No.: 9,061,236, Zhuying Wang, Hong Qian, Yuanming Liao and Tao Bai. 2015.
2.“Rapid electrophoresis binding method and related kits and compositions”. Patent No.: 8,968,541, Zhuying Wang, Jinyu Yang, Fanli Meng, Bing Lai, Zhan Dai and Fangliang Zhang. 2015.
3.“Homologous recombination-based DNA cloning methods and compositions”. Patent No.: 8,815,600, Weiqiang Liu, Ping Yang, Tao Wang, Zhuying Wang, Wenzhu Chen and Fangliang Zhang. 2014.
4.“Metal nanoparticle structures for enhancing fluorescence-based assays”. Patent No.: 8,785,352, W. Mandecki, Ji li and Zhuying Wang. 2014.
5.“Methods and compositions for enhanced expression and secretion of proteins”. Patent No.: 8,603,780, Zhuying Wang and Xiaowu Liu. 2013.
6.“Homologous recombination-based DNA cloning compositions”. Patent No.: 8,501,454, Weiqiang Liu, Ping Yang, Tao Wang, Zhuying Wang, Wenzhu Chen and Fangliang Zhang. 2013.
7.“Composition Related to Rapid ELISA Process”. Patent No.: 8,334,103, Zhuying Wang, Fangliang Zhang and Tao Bai. 2012.
8.“Method of Sequence Optimization for improved recombinant protein expression using a particle swarm optimization algorithm”. Patent No.: 8,326,547, Xiaowu Liu, Yun He and Zhuying Wang. 2012.
9.“Rapid ELISA processes and related compositions”. Patent No.: 7,824,867, Zhuying Wang, Fangliang Zhang and Tao Bai. 2010.
10.“Rapid C-ELISA process and related compositions”. Patent No.: 7,816,092,Zhuying Wang, Fangliang Zhang and Tao Bai. 2010.
11.“Apparatus and method for detecting genetic mutations”. Patent No.: 7,279,280, Michael Pappas and Zhuying Wang. 2007.
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