•Education and Experience
2004-present State Key Laboratory of Applied Organic Chemistry, Lanzhou University,
Professor
2000-2004 Life Science College and State Key Laboratory of Applied Organic Chemistry,
post-doctoral fellow
1997-2000 Lanzhou University, Ph.D.
1994-1997 Lanzhou University, M.S.
1989-1993 Gannan Normal University, B.S.
•Honors and Rewards
2018 Member of the Executive, SFRBM of China
2014 Standing member of the biological effects Committee of reactive oxygen species,
Chinese society of environmental mutagens
2013 Director of free radical biology and free radical medicine branch of Chinese
society of Biophysics
2006 Supported by Program for New Century Excellent Talents in University
•Research Topics
Anticancer agents, Redox, Reactive Oxygen Species, Free Radical, Prooxidant, Medicinal chemistry, Chemical biology.
Altered redox homeostasis in cancer cells illustrates their redox vulnerability (termed as redox Achilles heel), and has opened a window for developing prooxidative anticancer agents to hit this status. Our research focuses on developing natural product-inspired prooxidative anticancer agents by exploiting the redox Achilles heel of cancer cells.
•Publications
1. Selective Imaging of Hydrogen Peroxide over Peroxynitrite by a Boronate-based Fluorescent Probe Engineered via a Doubly Activated Electrophilicity-Increasing Strategy. Di-Hua Tian†, Jun-Ru Liu†, Si-Yuan Wang, Shuai Yan, Zuo-Hu Chai, Fang Dai*, Shengxiang Zhang*, and Bo Zhou*, Sens. Actuators B Chem. 2022, 368, 132149.
2. A Coumarin-Based Fluorescent Probe: Small but Multi-Signal. Ya-Long Zheng†, Xiao-Chun Li†, Wei Tang, Li Xie, Fang Dai*, and Bo Zhou*, Sens. Actuators B Chem. 2022, 368,132169.
3. Prooxidative Inhibition Against NF-κB-Mediated Inflammation by Pharmacological Vitamin C. Yu-Ting Du, Ying Long, Wei Tang, Xue-Feng Liu, Fang Dai, and Bo Zhou*. Free Radic. Biol. Med. 2022, 180, 85.
4. Developing Dietary Curcumin Mono-Carbonyl Piperidinone Analogs as Nrf2-Dependent Cytoprotectors Against Oxidative Damage: Structure-activity Relationship and Mechanisms. Xue-Feng Liu, Qi Wang, Jia-Fang Zheng, Zuo-Hu Chai, Fang Dai*, Xiao-Jie Jin* and Bo Zhou*, Free Radic. Biol. Med. 2022, 186, 66.
5. Michael Acceptor-Dependent Pro-oxidative Intervention against Angiogenesis by [6]-Dehydroshogaol, a Pungent Constituent of Ginger. Xuefeng Liu†, Yihua Wang†, Yalong Zheng, Dechen Duan, Fang Dai, and Bo Zhou*, Eur. J. Pharmacol. 2022, 925, 174990.
6. Developing Push-Pull Hydroxylphenylpolyenylpyridinium Chromophores as Ratiometric Two-Photon Fluorescent Probes for Cellular and Intravital Imaging of Mitochondrial NQO1, Yong-Peng Yang, Fu-Jian Qi, Yi-Ping Qian, Xia-Zhen Bao, Han-Chen Zhang, Bin Ma, Fang Dai*, Sheng-Xiang Zhang*, and Bo Zhou*, Anal. Chem. 2021, 93, 2385-2393.
7. Developing a styrylpyridinium-based fluorescent probe with excellent sensitivity for visualizing basal H2S levels in mitochondria, Bin Ma, Di-Hua Tian, Shuai Yan, Xiao-Chun Li, Fang Dai*, and Bo Zhou*, Sens. Actuators B Chem. 2021, 327, 128937.
8. A multi-signal mitochondria-targetable fluorescent probe for simultaneously discriminating Cys/Hcy/H2S, GSH, and SO2 and visualizing the endogenous generation of SO2 in living cells, Ya-Long Zheng, Zuo-Hu Chai, Wei Tang, Shuai Yan, Fang Dai*, Bo Zhou*. Sens. Actuators B Chem. 2021, 330, 129343.
9. Designing an ESIPT-based fluorescent probe for imaging of hydrogen peroxide during the ferroptosis process, Han-Chen Zhang, Di-Hua Tian, Ya-Long Zheng, Fang Dai, Bo Zhou*, Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 248, 119264.
10. A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells. Xiazhen Bao, Qi Wang, Xiaorong Ren, Fang Dai, and Bo Zhou*. Free Radical Bio. Med. 2020, 152, 597-608.
11. Inhibiting NF-κB-Mediated Inflammation by Catechol-Type Diphenylbutadiene via an Intracellular Copper- and Iron-Dependent Pro-Oxidative Role. Fang Dai, Yuting Du, Yalong Zheng, and Bo Zhou*. J. Agr. Food Chem. 2020, 68, 10029-10035.
12. Cooperation of ESIPT and ICT Processes in the Designed 2-(2′-Hydroxyphenyl)benzothiazole Derivative: A Near-Infrared Two-Photon Fluorescent Probe with a Large Stokes Shift for the Detection of Cysteine and Its Application in Biological Environments. Ying Long, Junru Liu, Dihua Tian, Fang Dai*, Shengxiang Zhang*, and Bo Zhou*. Anal. Chem. 2020, 92,14236-14243.
13. A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent. Fang Dai#, Yuting Du#, Yalong Zheng, and Bo Zhou*. Free Radical Bio. Med. 2019, 130, 489-498.
14. Identification of catechol-type ddiphenylbutadiene as a tyrosinase-activated pro-oxidative chemosensitizer against melanoma A375 Cells via glutathione S-transferase inhibition. Yuan Ji, Fang Dai, Shuai Yan, Jingyang Shi, and Bo Zhou*. J. Agr. Food Chem. 2019, 67, 9060-9069.
15. Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs. Xiazhen Bao, Fang Dai, Qi Wang, Xiaoling Jin, and Bo Zhou*, Free Radical Bio. Med. 2019, 134, 406-418.
16. Developing a julolidine-fluorescein-based hybrid as a highly sensitive fluorescent probe for sensing and bioimaging cysteine in living cells. Yuan Ji, Fang Dai, and Bo Zhou*. Talanta 2019, 197, 631-637.
17. Keto-enol-based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells. Fang Dai, Cuihong Yuan, Yuan Ji, Yuting Du, Xiazhen Bao, Lingxi Wu, Xiaoling Jin, and Bo Zhou*. Free Radical Bio. Med. 2018, 120, 124-132.
18. A 1,8-naphthalimide-based turn-on fluorescent probe for imaging mitochondrial hydrogen peroxide in living cells. Fang Dai, Fang Jin, Ying Long, Xiaoling Jin, and Bo Zhou*. Free Radical Res. 2018, 52, 1288-1295.
19. ROS-driven and preferential killing of HepG2 over L-02 cells by a short-term cooperation of Cu(II) and a catechol-type resveratrol analog. Fang Dai, Qi Wang, Guijuan Fan, Yuting Du, and Bo Zhou*. Food Chem. 2018, 250, 213-220.
20. Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone. Xiazhen Bao, Fang Dai, Xinrong Li, and Bo Zhou*. Free Radical Bio. Med. 2018, 124, 342-352.
21. A Catechol-Type Resveratrol Analog Manifests Antiangiogenic Action by Constructing an Efficient Catalytic Redox Cycle with Intracellular Copper Ions and NQO1. Yihua Wang, Fang Dai, and Bo Zhou*. Mol. Nutr. Food Res. 2018, 62, 1700969.
22. Applying an Electrophilicity-Based Strategy to Develop a Novel Nrf2 Activator Inspired from Dietary [6]-Shogaol. Yuting Du, Yalong Zheng, Yuan Ji, Fang Dai*, Yongjing Hu, and Bo Zhou*. J. Agr. Food Chem. 2018, 66, 7983-7994.
23. Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells. Yuan Ji, Fang Dai, and Bo Zhou*. Free Radical Bio. Med. 2018, 129, 215-226.
24. Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals. Fang Dai, Wenjing Yan, Xing Fu, Yalong Zheng, Yuting Du, Xiazhen Bao, Yanfei Kang, Xiaoling Jin, and Bo Zhou*. Eur. J. Med. Chem. 2018, 159, 317-323.
25. Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores. FangDai, WenjingYan, YutingDu, Xiazhen Bao, Xiuzhuang Li, and Bo Zhou*. Free Radical Bio. Med. 2017, 108, 554-563.
26. Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death. Zhishan Tu, Qi Wang, DandanSun, FangDai, and BoZhou*. Eur. J. Med. Chem. 2017, 134, 72-85.
27. Developing piperlongumine-directed glutathione S-transferase inhibitors by an electrophilicity-based strategy. Haibo Wang, Xiaoling Jin, Jiafang Zheng, Fu Wang, FangDai, and BoZhou*. Eur. J. Med. Chem. 2017, 126, 517-525.
28. Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation. WenjingYan, Qi Wang, Cuihong Yuan, Fu Wang, Yuan Ji, Fang Dai, Xiaoling Jin, and BoZhou*. Free Radical Bio. Med. 2016, 97, 109-123.
29. Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. Dong Lin, Fang Dai, Landi Sun, and Bo Zhou*. Mol. Nutr. Food Res. 2015, 59, 2395-2406.
30. Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention. Yan Li, Liping Zhang, Fang Dai, Wenjing Yan, Haibo Wang, Zhihan Tu, and Bo Zhou*. J. Agr. Food Chem. 2015, 63, 7731-7742.
31. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Respons. Tao Shen, Tao Jiang, Min Long, Jun Chen, Dongmei Ren, Pak Kin Wong, Eli Chapman*, Bo Zhou*, and Donna D. Zhang*. Antioxid. Redox Sign. 2015, 23, 651-664.
32. Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids. FangDai, Guoyun Liu, Yan Li, Wenjing Yan, Qi Wang, Jie Yang, Dongliang Lu, Dejun Ding, Dong Lin, and Bo Zhou*. Free Radical Bio. Med. 2015, 85, 127-137.
33. Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent. Landi Sun, Fu Wang, Fang Dai, Yihua Wang, Dong Lin, Bo Zhou*. Biochem. Pharmacol. 2015, 95, 156-169.
34. Tailoring 3,3' -Dihydroxyisorenieratene to Hydroxystilbene: Finding a Resveratrol Analogue with Increased Antiproliferation Activity and Cell Selectivity. Yanfei Kang, Wenjing Yan, Tingwen Zhou, Fang Dai, Xiuzhuang Li, Xiazhen Bao, Yuting Du, Cuihong Yuan, Haibo Wang, Xiaorong Ren, Qiang Liu, Xiaoling Jin, Bo Zhou*, Jie Zhang*. Chem.- Eur. J. 2014, 20, 8904-8908.
Copyrights © All Rights Reserved. State Key Laboratory of Applied Organic Chemistry 
SEARCH
