Education and Experience
2015-Date State Key Laboratory of Applied Organic Chemistry, College of chemistry
and Chemical Engineering, Lanzhou University, Professor
2012-2015 University of California, Berkeley & Lawrence Berkeley National Laboratory
(Tutor: F. Dean Toste; Paul Alivisatos), Post-doctoral
2010-2012 University of Wisconsin–Madison (Tutor: Weiping Tang), Post-doctoral
2005-2010 Lanzhou University (Tutor: Yongmin Liang), Ph.D.
2001-2005 Shaoxing University, B.S.
Honors and Awards
2020 Thieme Chemistry Journals Award
2009 China Youth Science and Technology Innovation Award
2009 Chinese Academy of Sciences Scholarship
2008 Baosteel Excellent Student Award
2005 Zhejiang Province Government Award for “Outstanding University Graduates”
Research Topics
The Shu lab is focused on the development of catalysts, catalytic reactions and methods for organic synthesis. Especially, we are developing nickel- and cobalt-catalyzed cross-electrophile reactions to address problems associated with conventional cross-coupling reactions. There are three main research topics in this field, including: (1) The reductive functionalization of C-O/C-N bonds; (2) Asymmetric cross-electrophile reactions of alkenes; (3) Organosilicon chemistry.
Publications
1. Enantioselective Reductive N‑Cyclization Alkylation Reaction of Alkene-Tethered Oxime Esters and Alkyl Iodides by Nickel Catalysis. Xuegong Jia, Qiwei Yao, and Xingzhong Shu*, J. Am. Chem. Soc. 2022, 144, 13461.
2. Nickel-Catalyzed Reductive C(sp2)-Si Coupling of Chlorohydrosilanes via Si-Cl Cleavage. Zhenzhen Zhao, Xiaobo Pang, Xiaoxue Wei, Xueyuan Liu and Xingzhong Shu*, Angew. Chem. Int. Ed. 2022, 61, e202200215.
3. Nickel-Catalyzed Cross-Electrophile 1,2-Silyl-Arylation of 1,3-Dienes with Chlorosilanes and Aryl Bromides. Qiuquan Pan, Liangliang Qi, Xiaobo Pang, and Xing-Zhong Shu*, Angew. Chem. Int. Ed. 2022, DOI:10.1002/anie.202215703, e202215703.
4. Reductive Cross-Coupling of Unreactive Electrophiles. Xiaobo Pang, Pei-Feng Su, and Xing-Zhong Shu*, Acc. Chem. Res. 2022, 55, 2491.
5. Ti-Catalyzed Reductive Dehydroxylative Vinylation of Tertiary Alcohols. Hao Xie, Sheng Wang, Yuquan Wang, Peng Guo and Xing-Zhong Shu*, ACS Catal. 2022, 12, 1018.
6. Reductive Alkylation of Alkenyl Acetates with Alkyl Bromides by Nickel Catalysis. Rong-De He, Yunfei Bai, Guan-Yu Han, Zhen-Zhen Zhao, Xiaobo Pang, Xiaobo Pan, Xue-Yuan Liu, Xing-Zhong Shu*. Angew. Chem. Int. Ed. 2021, 61, DOI:10.1002/anie.202114556
7. Nickel-Catalyzed Reductive C−Ge Coupling of Aryl/Alkenyl Electrophiles with Chlorogermanes. Pei-Feng Su‡, Ke Wang‡, Xuejing Peng, Xiaobo Pang, Peng Guo, and Xing-Zhong Shu*. Angew. Chem. Int. Ed. 2021, 60, 26571-26576.
8. Cobalt-Catalyzed Enantiospecific Dynamic Kinetic Cross-Electrophile Vinylation of Allylic Alcohols with Vinyl Triflates. Wei-Yuan Ma, Guan-Yu Han, Shaolin Kang, Xiaobo Pang, Xue-Yuan Liu, Xing-Zhong Shu. J. Am. Chem. Soc. 2021, 143, 15930-15935.
9. Enantioselective Reductive Divinylation of Unactivated Alkenes by Nickel-Catalyzed Cyclization Coupling Reaction. Jin-Bao Qiao‡, Ya-Qian Zhang‡, Qi-Wei Yao, Zhen-Zhen Zhao, Xuejing Peng, and Xing-Zhong Shu. J. Am. Chem. Soc. 2021, 143, 12961-12967.
10. Regiocontrolled Reductive Vinylation of Aliphatic 1,3-Dienes with Vinyl Triflates by Nickel Catalysis. Xiaobo Pang, Zhen-Zhen Zhao, Xiao-Xue Wei, Liangliang Qi, Guang-Li Xu, Jicheng Duan, Xue-Yuan Liu, and Xing-Zhong Shu. J. Am. Chem. Soc. 2021, 143, 4536-4542.
11. Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis. Peng Guo, Ke Wang, Wen-Jie Jin, Hao Xie, Liangliang Qi, Xue-Yuan Liu, and Xing-Zhong Shu. J. Am. Chem. Soc. 2021, 143, 513-523.
12. Nickel-Catalyzed Cross-Electrophile C(sp3)-Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes. Jicheng Duan, Yuquan Wang, Liangliang Qi, Peng Guo, Xiaobo Pang, Xing-Zhong Shu*, Org. Lett. 2021, 23, 7855-7859.
13. Nickel-Catalyzed Cross-Electrophile C(sp3)–Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes. CCS Chem.2021, 3, 1147-1154.
14. Titanium: a Unique Metal for Radical Dehydroxylative Functionalization of Alcohols. Xiaobo Pang, Xing-Zhong Shu*, Synlett 2021, 32, 1269-1274.
15. Synthesis of Dibenzyls Synthesis by Nickel-Catalyzed Homocoupling of Benzyl Alcohols. Feng-Feng Pan, Peng Guo, Xiaochuang huang, Xing-Zhong Shu*, Synthesis-Stuttgart 2021, 53, 3094-3100.
16. Cross-Electrophile Csp2-Si Coupling of Vinyl Chlorosilanes. Jicheng Duan, Ke Wang, Guangli Xu, Shaolin Kang, Liangliang Qi, Xueyuan Liu, and Xingzhong Shu*. Angew. Chem. Int. Ed. 2020, 59, 23083-23088.
17. Radical Dehydroxylative Alkylation of Tertiary Alcohols by Ti Catalysis. Hao Xie, Jiandong Guo, Yuquan Wang, Ke Wang, Peng Guo, Peifeng Su, Xiaotai Wang*, and Xingzhong Shu*. J. Am. Chem. Soc. 2020, 142, 16787-16794.
18. Allylboronates from Vinyl Triflates and α-Chloroboronates by Reductive Nickel Catalysis. Jinbao Qiao, Zhenzhen Zhao, Yaqian Zhang, Kai Yin, Zhixiong Tian, and Xingzhong Shu*. Org. Lett. 2020, 22, 5085-5089.
19. Reductive Coupling between C-N and C-O Electrophiles. Rongde He, Chunling Li, Qiuquan Pan, Peng Guo, Xueyuan Liu, and Xingzhong Shu*. J. Am. Chem. Soc. 2019, 141, 12481-12486.
20. Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes. Zhixiong Tian, Jinbao Qiao, Guangli Xu, Xiaobo Pang, Liangliang Qi, Weiyuan Ma, Zhenzhen Zhao, Jicheng Duan, Yunfei Du, Peifeng Su, Xueyuan Liu, and Xingzhong Shu*. J. Am. Chem. Soc. 2019, 141, 7637-7643.
21. Ni-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptides. Jicheng Duan, Yunfei Du, Xiaobo Pang, and Xingzhong Shu*. Chem. Sci. 2019, 10, 8706-8712.
22. Enones from Acid Fluorides and Vinyl Triflates by Reductive Nickel Catalysis. Fengfeng Pan, Peng Guo, Chunling Li, Peifeng Su, and Xingzhong Shu*. Org. Lett. 2019, 21, 3701-3705.
23. Dual nickel and Lewis acid catalysis for cross-electrophile coupling: the allylation of aryl halides with allylic alcohols. Xuegong Jia, Peng Guo, Jicheng Duan, and Xingzhong Shu*. Chem. Sci. 2018, 9, 640-645.
24. Reductive coupling of benzyl oxalates with highly functionalized alkyl bromides by nickel catalysis. Xiaobiao Yan, Chunling Li, Wenjie Jin, Peng Guo, and Xingzhong Shu*. Chem. Sci. 2018, 9, 4529-4534.
25. Silica-Supported Cationic Gold(I) Complexes as Heterogeneous Catalysts for Regio- and Enantioselective Lactonization Reactions. Xingzhong Shu, Son C. Nguyen, Ying He, Fadekemi Oba, Qiao Zhang, Christian Canlas, Gabor A. Somorjai*, A. Paul Alivisatos*, and F. Dean Toste*. J. Am. Chem. Soc. 2015, 137, 7083.
26. Dual Visible Light Photoredox and Gold-catalyzed Arylative Ring Expansion. Xingzhong Shu, Miao Zhang, Ying He, Heinz, Frei*, and F. Dean Toste*. J. Am. Chem. Soc. 2014, 136, 5844.
27. Transfer of Chirality in Rhodium-Catalyzed Intramolecular (5+2) Cycloaddition of 3-Acyloxy-1, 4-enyne (ACE) and Alkyne: Enantioselective Synthesis of Bicyclo[5.3.0]decatrienes. Xingzhong Shu, Casi M. Schienebeck, Wangze Song, Ilia A. Guzei, and Weiping Tang*. Angew. Chem. Int. Ed. 2013, 52, 13601.
28. Rhodium-Catalyzed Intra- and Intermolecular 5+2 Cycloaddition of 3-Acyloxy-1, 4-enyne and Alkyne with Concomitant 1, 2-Acyloxy Migration, Xingzhong Shu, Xiaoxun Li, Dongxu Shu, Suyu Huang, Casi Mae Schienebeck, Xin Zhou, Patrick J. Robichaux, and Weiping Tang. J. Am. Chem. Soc. 2012, 134, 5211.
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