2012-Present Associate Professor, College of chemistry and Chemical Engineering,
State Key Laboratory of Applied Organic Chemistry, Lanzhou University
2009-2012 Postdoc, Novartis Institute for Biomedical Research (NIBR)
2004-2009 D.S., Shanghai Institute of Organic Chemistry, CAS. (Advisor: Yikang Wu)
2000-2004 B.S., Sichuan University
· Honors and Rewards
2020 Thieme Chemistry Journals Award
2019 Young scholars of Gansu Province "Flying scholar special recruitment plan"
2019 Asian Core Project "ACP Lectureship Award"
· Research Topics
Natural Product Total Synthesis
Synthetic Methodology development
Our laboratory pursues synthetic strategies and chemical reactions that have the potential to advance the field of organic synthesis. We set out to rapidly generate the molecular structures of biologically active natural products by utilizing the ample reactivities of alkyne. Currently, synthetic methodology development in our group is primarily focused on the four activation modes of alkyne, such as hetero-atom activation; triazole pre-activation; transitional-metal activation and isomerization reactions. We always enjoy the opportunities of utilizing our own-developed methodology in bioactive natural product total synthesis.
· Publications
1. Diastereoselective Ring Expansion of Cyclic Ketones Enabled by Hat-Initiated Radical Cascade. Wenxue Wang, Shouyang Feng, Yansheng Wei, Hongyu Wang, and Yun Li*, Org. Lett. 2023, 25, 8022.
2. Synthetic studies on pseudolaric acid B: Enantioselective synthesis of C4,C10-di-epi-trans-fused [5-7]-bicyclic skeleton. Rui Guo, Hongbin Zhai*, and YunLi*. Chin. Chem. Lett. 2021, 32, 1400-1402.
3. Enantioselective Total Synthesis of (+)-Arboridinine. Zhang Zhen, Xie Sujun, Cheng Bin, Zhai Hongbin*, and Li Yun*. J. Am. Chem. Soc. 2019, 141, 7147-7154.
4. Facile Synthesis of Pyridines from Propargyl Amines: Concise Total Synthesis of Suaveoline Alkaloids. Zhao Zhiwen, Wei Hongbo, Xiao Ke, Cheng Bin, Zhai Hongbin, and Li Yun*. Angew. Chem. Int. Ed. 2019, 58, 1148-1152.
5. Stereoselective Synthesis of Spiro-2-oxabicyclo[2.2.2]octane Enabled by Ag(I)/ Brønsted Acid Relay Catalysis. Zhang Qingyu, Wang Jianping, Wei Yansheng, Zhai Hongbin, and Li Yun*. Org. Lett. 2019, 21, 1694-1698
6. Quick Access to Pyridines through 6π-3-Azatriene Electrocyclization: Concise Total Synthesis of Suaveoline Alkaloids. Wei Hongbo, and Li Yun*. Synlett 2019, 30, 1615-1620.
7. Relay Catalysis of Rh (II) and Cobaloxime: Stereoselective Synthesis of Spiroindanones from N-Sulfonyl-1,2,3-triazoles. Zhao Liu, Qiuchen Du, Hongbin Zhai, and Yun Li*. Org. Lett. 2018. 20, 7514-7517.
8. Organocatalytic Synthesis of 4-Aryl-1,2,3,4-tetrahydropyridines from Morita-Baylis-Hillman Carbonates through a One-Pot Three-Component Cyclization. Jian Wei, Yuntong Li, Cheng Tao, Huifei Wang, Bin Cheng, Hongbin Zhai*, and Yun Li*. J. Org. Chem. 2018, 83, 835-842.
9. The Expanding Utility of Rhodium-Iminocarbenes: Recent Advances in the Synthesis of Natural Products and Related Scaffolds. Yun Li*, Hongjian Yang, and Hongbin Zhai*. Chem.-Eur. J. 2018, 24, 12757-12766.
10. Bioinspired Total Synthesis of (±)-Chaetophenol C Enabled by a Pd-Catalyzed Cascade Cyclization. Yun Li*, Qingyu Zhang, Hongyu Wang, Bin Cheng, and Hongbin Zhai*. Org. Lett. 2017, 19, 4387-4390.
11. Rhodium-Catalyzed Denitrogenative [3+2] Cycloaddition: Access to Functionalized Hydroindolones and the Framework of Montanine-Type Amaryllidaceae Alkaloids. Hongjian Yang, Shengtai Hou, Cheng Tao, Zhao Liu, Chao Wang, Bin Cheng, Yun Li*, and Hongbin Zhai*. Chem.–Eur. J. 2017, 23, 12930-12936.
12. Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters. Shengtai Hou, Hongjian Yang, Bin Cheng, Hongbin Zhai*, and Yun Li*. Chem. Commun. 2017, 53, 6926-6929.
13.Rh-Catalyzed [3+2] Cycloaddition of 1-Sulfonyl-1,2,3-triazoles: Access to the Framework of Aspidosperma and Kopsia Indole Alkaloids. Yun Li*, Qingyu Zhang, Qiucheng Du, and Hongbin Zhai*. Org. Lett. 2016, 18, 4076-4079.
14. Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy. Hongbo Wei, Yun Li*, Ke Xiao, Bin Cheng, Huifei Wang, Lin Hu, and Hongbin Zhai*. Org. Lett. 2015, 17, 4076-4079.
15.Stereoselective Synthesis of (2Z)-2,4-Dienamides via NBS-Mediated Allyloxyl Addition-Claisen Rearrangement−Dehydrobromination Cascade Reaction of Ynsulfonamides. Runbo Ding, Yun Li*, Cheng Tao, Bin Cheng, and Hongbin Zhai*. Org. Lett. 2015, 17, 3994-3997.
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