Shaohua Wang

Ph.D.,Professor

Tel：

+86-931-8915686

E-Mail：

wangshh@lzu.edu.cn

2017-Present       Professor, School of Pharmacy、State Key Laboratory
                                   of Applied Organic Chemistry                     

2011-2017           Associate Professor, School of Pharmacy

2006-2011           Postdoc, Mayo Clinic (Advisor: Yuan-Ping Pang)

2001-2006           Ph. D., Lanzhou University (Advisor: Yong-Qiang Tu)

1997-2001           B. S., Lanzhou University (Advisor: Yong-Qiang Tu)

· Honors and Rewards

2018                     Chang Jiang Young Scholar of the Ministry of Education of China, sponsored
                                    by the Chang Jiang Scholars Program, the Ministry of Education, China 

2017                     Young Teacher Achievement Award of Regular Colleges and Universities
                                    in Gansu Province, Youth May Fourth Medal of Lanzhou University

2016                     Second prize of National Natural Science Award(Fourth Completer)

2015                     First Prize of Natural Science of Ministry of Education (Fourth Completer)

· Research Topics

The design and synthesis of bioactive molecules; total synthesis of natural products and the development of related synthetic methodology

· Publications

1. Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds. Tianlu Zheng, Ye Zhang, Along Gou, Fu Cheng, Sizhan Liu, Lan Yu*, Mingyue Cui, Xuetao Xu, Kun Zhang, and Shaohua Wang*. Org. Lett. 2020, 22, 7073-7077.

2. Direct Synthesis of 2-Substituted Benzonitriles via Alkylcyanation of Arynes with N,N-Disubstituted Aminomalononitriles. Wen Bao, Zhupeng Gao, Daping Jin, Caogen Xue, Huan Liang, Lingsheng Lei, Xuetao Xu, Kun Zhang, and Shaohua Wang*. Chem. Commun.  2020, 56, 7641-7644.

3. Al(OTf)₃-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues. Linsheng Lei, Bowen Wang, Daping Jin, Zhupeng Gao, Huanliang, Shaohua Wang*, Xuetao Xu, Kun Zhang, and Xiaoyun Zhang*. Adv. Synth. Catal.  2020, 362, 2870-2875.

4. Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence. Ye Zhang, Tianlu Zheng, Fu Cheng, Kunlong Dai, Kun Zhang, Aijun Ma, Fumin Zhang, Xiaoming Zhang, Shaohua Wang*, and Yongqiang Tu*. Chem. Sci. 2020, 11, 3878-3884.

5. A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton. Lin Liu, Linsheng Lei, Zongsong Zhan, Sizhan Liu, Yuxiao Wang, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang,  Aijun Ma, and Shaohua Wang *. Chem. Commun. 2019, 55, 3789-3792.

6. Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Liu, L.; Cheng, H.-L.; Ma, W.-Q.; Hou, S.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.*, Chem. Commun. 2018, 54 , 196-199.

7. Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. Bao, W.; Wang, J.-Q.; Xu, X.-T.; Zhang, B.-H.; Liu, W.-T.; Lei, L.-S.; Liang, H.; Zhang, K.; Wang, S.-H.*, Chem. Commun. 2018, 54, 8194-8197.

8. Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction. Lin Liu, Hailong Cheng, Wenqiang Ma, Sihua Hou, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, and  Shaohua Wang*.Org. Lett. 2017, 19, 4648-4651.

9. Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles. Banghong Zhang, Linsheng Lei, Sizhan Liu, Xueqing Mou, Weiting Liu, Shaohua Wang*, Jie Wang*, Wen Bao, and  Kun Zhang.  Chem. Commun. 2017, 53, 8545-8548.

10. Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis. Xiaoming Zhang , Yongqiang Tu*, Fumin Zhang, Zhihua Chen, and Shaohua Wang*. Chem. Soc. Rev. 2017, 46, 2272-2305.

11. Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice. Xuetao Xu, Xueqing Mou, Qinmei Xi, Weiting Liu, Wenfeng Liu, Zhaojun Sheng, Xi Zheng, Kun Zhang, Zhiyun Du, Suqing Zhao, ShaohuaWang*. Bioorg. Med. Chem. Lett. 2016, 26, 5334-5339.

12. The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction. Xueqing Mou, Zhengliang Xu, Li Xu, Shaohua Wang*, Banghong Zhang, Di Zhang, Jie Wang, Weiting Liu, and Wen Bao. Org. Lett. 2016, 18, 4032-4035.

13. A Tin(IV) Chloride Promoted Tandem C-O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes. Chao Yang, Zhengliang Xu, Hui Shao, Xueqing Mou, Jie Wang, and Shaohua Wang*. Org. Lett. 2015, 17, 5288-5291.

14. An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole. Xueqing Mou, Zhengliang Xu, Shaohua Wang*, Daoyong Zhu, Jie Wang, Wen Bao, Shijiang Zhou, Chao Yang, and Di Zhang. Chem. Commun. 2015, 51, 12064-12067.

15. Catalytic asymmetric semipinacol rearrangements. Shaohua Wang, Baosheng Li, and  Yongqiang Tu*. Chem. Commun. 2014, 50, 2393-2408.

16. Copper-catalyzed intermolecular azidocyanation of aryl alkenes. Li Xu, Xueqing Mou, Zhimin Chen,and Shaohua Wang*. Chem. Commun. 2014, 50, 10676-10679.

17.Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)-Lycojaponicumin C, (−)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine.  Sihua Hou, Yongqiang Tu*, Lin Liu,  Fumin Zhang, Shaohua Wang*, and Xiaoming Zhang. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.