2023-present Professor,State Key Laboratory of Applied Organic Chemistry & College
of Chemistry and Chemical Engineering, Lanzhou University
2016-2022 Professor, School of Pharmaceutical Sciences, South Central University
for Nationalities
2001-2015 Associate Research Professor, Wenzhou University
2013-2014 Postdoc, Nanjing University (Advisor: Prof. Ren-Xiang Tan)
2010-2011 Research Assistant, Yale University (Advisor: Prof. Yinqun Huang)
2007-2012 Ph.D., Chengdu Institute of Biology, Chinese Academy of Sciences
(Supervisors: Prof. Anjiang Zhang and Lisheng Ding),
2005-2007 M. S.,Wenzhou University (Advisor: Prof. Anjiang Zhang and Lixue Zhang)
1997-2001 B. S., South Central U Minzu University,
· Honors and Awards
2022 Magnetic Resonance in Chemistry, the member of advisory board
2021 NMR symposium and workshop in drug discovery(Nanjing), Co-chair
2020 Magnetic Resonance Letters, the member of the editorial board
2018 Natural Products and Bioprospecting, the member of the editorial board
2014 Set up the Sino-German Symposium on Novel NMR method for Organic
Chemistry(Wenzhou)
2014 Award for Science and Technology of China Association for Instrumental Analysis
· Research Topics
Developing new NMR methodologies for analyzing the structure of organic molecules oriented in weak alignment media. Furthermore, we expand the developed alignment media to the application to anisotropic parameters including residual dipolar coupling (RDC), residual chemical shift anisotropy (RCSA), and nuclear quadrupole resonance (NQR). We also carry out structural analyses of natural and synthetic small organic molecules and analysis of the conformation of drug or active molecules using the anisotropic enhanced NMR. We are also interested in the development of phage and mRNA display technologies for cyclic peptide screening to the disease target protein or RNA.
· Publication
1. Programmable Alignment Media from Self-Assembled Oligopeptide Amphiphiles for the Measurement of Independent Sets of Residual Dipolar Couplings in Organic Solvents. Lin, Yuexiao; Li, Jiaqian; Qin, Si-Yong; Sun, Han; Yang, Yan-Ling; Navarro-Vazquez, Armando; Lei, Xinxiang*,Chemical Science, 2022, 13, 5838-5845. Chem Sci Pick of Week, Hot Article Collection, inside back cover.
2. Peptide Probes with High Affinity to Target Protein Selection by Phage Display and Characterization Using Biophysical Approaches. Yang, Xiao-Qin; Bai, Li-Wen; Chen, Yu; Lin, Yue-Xiao; Xiang, Hua; Xiang, Ting-Ting; Zhu, Shuang-Xing; Zhou, Li; Li, Kai*; Lei, Xinxiang* ,New J. Chem., 2022, 46, 10299-10307.
3. Ti3C2Tx MXene Liquid Crystal: Access to Create Background-Free and Easy-Made Alignment Medium. Zhao, You; Yu, Qinghua; Cheng, Wei-Wei; Li, Jia-Qian; Zhang, Ai-Qing; Lei, Xinxiang*; Yang, Yingkui; Qin, Si-Yong *, ACS Nano, 2022,16, 5454-5462.
4. Structural Elucidation of Garcipaucinones A and B From Garcinia paucinervis Using Quantum Chemical Calculations. Tan, Xue; Han, Xiaoyang; Teng, Haida; Li, Qingqing; Chen, Yu; Lei, Xinxiang*; Yang, Guangzhong*, J. Nat. Prod., 2021, 84, 972–978.
5. Solvent-Tailored Ordered Self-Assembly of Oligopeptide Amphiphiles to Create an Anisotropic Meso-matrix. Jiang, Yan; Zhao, You; Zhang, Ai-Qing; Lei, Xinxiang*; Qin, Si-Yong*, Chem. Commun., 2021, 57, 6181-6184.
6. Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid Crystalline Based Medium. Qin, Si-Yong*; Jiang, Yan; Sun, Han; Liu, Han; Zhang, Ai-Qing; Lei, Xinxiang*, Angew. Chem. Int. Ed., 2020, 59, 17097-17103. Hot Paper.
7. Enantioselective Pd-Catalyzed Hydrofluorination of Vinylarenes. Yin, Xuemei; Chen, Bin; Qiu, Feng; Wang, Xihong; Liao, Yang; Wang, Min; Lei, Xinxiang*; Liao, Jian*, ACS Catal., 2020, 10, 1954−1960.
8. Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. Li, Xiao-Lu; Chi, Lu-Ping; Navarro-Vazquez, Armando; Hwang, Songhwan; Schmieder, Peter; Li, Xiao-Ming; Li, Xin; Yang, Sui-Qun; Lei, Xinxiang*; Wang, Bin-Gui*; Sun, Han*, J. Am. Chem. Soc., 2020, 142, 2301−2309.
9. Practical Aspects of Oligopeptide AAKLVFF as an Alignment Medium for the Measurements of Residual Dipolar Coupling of Organic Molecules. Liu, Han; Chen, Pian; Li, Xiao-Lu; Sun, Han; Lei, Xinxiang*, Magn. Reson. Chem., 2020, 58,404-410.
10. Herpotrichones A and B, Two Intermolecular [4 + 2] Adducts with Anti-Neuroinflammatory Activity from a Herpotrichia Species. Han, Wen-Bo; Wang, Guang-Yi; Tang, Jiang-Jiang; Wang, Wen-Ji; Liu, Han; Gil, Roberto R.; Navarro-Vazquez, Armando; Lei, Xinxiang*; Gao, Jin-Ming*, Org. Lett., 2020, 22, 405−409.
11. Directing an Oligopeptide Amphiphile into an Aligned Nanofiber Matrix for Elucidating Molecular Structures. Qin, Si-Yong*; Ding, Wen-Qiang; Jiang, Zhi-Wei; Lei, Xinxiang*; Zhang, Ai-Qing*, Chem. Commun., 2019, 55, 1659-1662.
12. Enantiomeric NMR Discrimination of Carboxylic Acids Using Actinomycin D as a Chiral Solvating Agent. Bai, Liwen; Chen, Pian; Xiang, Jiangxia; Sun, Jiarui; Lei, Xinxiang*, Org. Biomol. Chem., 2019, 17, 1466-1470.
13. Residual Dipolar Couplings in Structure Determination of Natural Products. Li, Gao-Wei; Liu, Han; Qiu, Feng; Wang, Xiao-Juan; Lei, Xin-Xiang*, Natur. Prod. & Bioprosp., 2018, 8, 279-295.
14. A Self-Assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurement of Residual Dipolar Couplings in Methanol. Lei, Xinxiang*; Qiu, Feng; Sun, Han; Bai, Liwen; Wang, Wen-Xuan; Xiang, Wensheng; Xiao, Hongping, Angew. Chem. Int. Ed., 2017, 56, 12857-12861.
15. Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Li, Gao-Wei; Cao, Jiang-Ming; Zong, Wen; Hu, Li; Hu, Mao-Lin; Lei, Xinxiang*; Sun, Han*; Tan, Ren Xiang*, Chem. Eur. J., 2017, 23, 7653-7656.
16. An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes. Zong, Wen; Li, Gao-Wei; Cao, Jiang-Ming; Lei, Xinxiang*; Hu, Mao-Lin; Sun, Han*; Griesinger, Christian; Tan, Ren Xiang*, Angew. Chem. Int. Ed., 2016, 55, 3690-3693.
17. Enantiodiscrimination of Carboxylic Acids Using the Diphenylprolinol NMR Chiral Solvating Agents. Li, Gaowei; Cao, Jiangming; Zong, Wen; Lei, Xinxiang*; Tan, Renxiang*, Org. Chem. Front., 2016, 3, 96-102.
18. Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents. Lei, Xinxiang*; Xu, Zhen; Sun, Han; Wang, Shun; Griesinger, Christian; Peng, Li; Gao, Chao*; Tan, Ren X*, J. Am. Chem. Soc., 2014, 136, 11280-11283.
19. A Novel Amine Receptor Based on the Binol Scaffold Functions as a Highly Effective Chiral Shift Reagent for Carboxylic Acids. Ma, Qingzhu; Ma, Minshan; Tian, Hongying; Ye, Xiaoxia; Xiao, Hongping; Chen, Lian-hui*; Lei, Xinxiang*, Org. Lett., 2012, 14, 5813-5815.
20. Determinants of mRNA Recognition and Translation Regulation by Lin28. Lei, Xin-Xiang; Xu, Jie; Ma, Wei; Qiao, Chong; Newman, Martin A.; Hammond, Scott M.; Huang, Yingqun*, Nucleic Acids Res., 2012, 40, 3574-3584.
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