2023-Present Professor, State Key Laboratory of Applied Organic Chemistry &
College of Chemistry and Chemical Engineering, Lanzhou University, China
2014-2023 Associate Professor, State Key Laboratory of Applied Organic Chemistry &
College of Chemistry and Chemical Engineering, Lanzhou University, China
2009-2013 Lecturer, State Key Laboratory of Applied Organic Chemistry &
College of Chemistry and Chemical Engineering, Lanzhou University, China
2016-2017 The Scripps Research Institute (Advisor: Ben Shen), visiting scholar
2004-2009 Lanzhou University (Advisor: Kun Gao), D.Sc
2000-2004 Xinzhou Teachers University, B.Sc
· Research Topics
1. Efficient discovery, structural modification and biological activity of natural products with novel structure;
2. Chemical constituents of traditional Chinese medicine based on synthetic biology.
· Publications
1. Euphohelides A−C, Ent-Abietane-Type Norditerpene Lactones from Euphorbia Helioscopia and their Anti-Inflammatory Activities. Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen*, and Kun Gao*, J. Nat. Prod., 2023, 86, 1003.
2. Ent-Atisane Diterpenoids from Euphorbia Helioscopia and their Anti-Inflammatory Activities. Hong-Ying Yang, Mei-Lian Wen, Shi-Jing Fu, Yu-Bo Lu, Ru-Ling Liu, Kun Gao*, and Jian-Jun Chen*, Chem. Biodivers., 2023, 20, e202301454.
3. Azaphilones from the Fungus Penicillium Multicolor Lzuc-S2 and their Antibacterial Activity. Shi-Jin Shen, Zi-Yun Feng, Song-Jie Jiang, Li Liu, Shi-Jing Fu, Wan-Hong Chen, Qi-Yue Sun, Jian-Jun Chen*, Chem. Biodivers., 2023, 20, e202201180.
4. Euphohelides A−C, ent-Abietane-Type Norditerpene Lactones from Euphorbia helioscopia and Their Anti-Inflammatory Activities. Yang, H. Y.; Yao, W.; Huang, P. Z.; Xu, H.; Ma, Q.; Chen, X.; Chen, J. J.*; Gao, K.*. J. Nat. Prod. 2023, 86, 1003−1009.
5. Jatrophane diterpenoids with cytotoxic activity from the whole plant of Euphorbia heliosocpia L. Lu, Y. B.; Luo, S.; Wang, Y. X.; Feng, Z. Y.; Gao, K.*; Chen, J. J.* Phytochemistry, 2022, 203, 113420.
6. Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica. Chen, J. J.; Bai, W.; Lu, Y.B.; Feng,Z.Y.; Gao, K.*; Yue, J. M.*; J. Nat. Prod. 2021, 84, 2111−2120.
7. Labdane-Type Diterpenoids from Leonurus japonicus and Their Plant-Growth Regulatory Activity. Li, H. Y.; Peng, X.; Jin, X.; Wei,W. J.; Ma, K. L.; Li, Y.; Chen, J. J.*; Gao, K.* J. Nat. Prod. 2019, 82, 2568−2579.
8. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity. Bai, W; Yang, H. Y.; Jiao, X. Z.; Feng, K. N.; Chen, J. J. *; Gao, K.* J. Nat. Prod. 2018, 81, 1777−1785.
9. Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity. Chen, J. J.#; Rateb, M. E. #; Love, M. S.; Xu, Z.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L. X.; Jiang, Y.; Duan, Y.; McNamara, C. W., Shen B. * J. Nat. Prod. 2018, 81, 791−797. (# contributed equally)
10. Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. Yan, X.#; Chen, J. J.#; Adhikari, A.; Teijaro, C. N. Ge, H.; Crnovcic, I.; Chang, C. Y.; Annaval, T.; Yang, D.; Rader, C.; Shen B. * Org. Lett. 2018, 20, 5918−5921. (# contributed equally)
11. Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria. Zeng, J.; Zhang, D. B.; Zhou, P. P.; Zhang, Q. L.; Zhao, L.; Chen, J. J.*; Gao, K. * Org. Lett. 2017, 19, 3998−4001.
12. Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. Yan, X.#; Chen, J. J.#; Adhikari, A.; Yang, D.; Crnovcic, I.; Wang, N.; Chang, C. Y.; Rader, C.; Shen, B.* Org. Lett. 2017, 19, 6192−6195. (# contributed equally)
13. Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia f ischeri. Gobu, F. R.; Chen, J. J.*; Zeng, J.; Wei, W. J.; Wang, W. F.; Lin, C. J.; Gao, K.* J. Nat. Prod. 2017, 80, 2263−2268.
14. Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents. Xu, Y. Z.; Gu, X. Y.; Peng, S. J.; Fang, J. G.; Zhang, Y. M.; Huang, D. J.; Chen, J. J.*; Gao, K.* Eur. J. Med. Chem., 2015, 94, 284−297.
15. Eremophilane-Type Sesquiterpenoids with Diverse Skeletons from Ligularia sagitta. Chen, J. J., Chen, C. J.; Yao, X. J.;Jin, X. J.; Gao K. *J. Nat. Prod. 2014, 77, 1329−1335.
16. Synthesis and Structure−Activity Relationships of N‑Methyl-5,6,7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents. Zhao, D. G.; Chen, J. J.; Du, Y. R.; Ma, Y. Y.; Chen, Y. X.; Gao K.*; Hu, B. R. * J. Med. Chem. 2013, 56, 1467−1477.
17. Absolute Structures of Monoterpenoids with a δ-Lactone-Containing Skeleton from Ligularia hodgsonii. Chen, J. J.; Li, W. X.; Gao K.*; Jin, X. J.; Yao, X. J. J. Nat. Prod. 2012, 75, 1184−1188.
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