Hui Sun

Ph.D., Professor

Tel：

13126587757

E-Mail：

sunhui@lzu.edu.cn

· Honors And Awards

Leading Talent of Gansu Province

Selected Candidate of the National Overseas High-Level Talent Recruitment Programs

Recipient of the Gansu Province Youth Science and Technology Award

· Research Topics

The research team is focusing on the interactions between diseases prevalent in this region and gut symbiotic bacteria. By leveraging authentic medicinal materials native to the Northwest and a natural product library derived from gut microbiota, we aim to develop lead compounds for treating these prevalent diseases. Currently, we have established systems for the isolation and in vitro cultivation of human gut bacteria and have constructed gut microbiota libraries representing major ethnic groups in Northwest China—including Han, Hui, Tibetan, Yugur, Kazakh, Tajik, and Uyghur—collecting over a thousand strains of gut bacteria. We have developed high-throughput functional screening systems in cell lines and organoids to screen the functional properties of natural products derived from gut bacteria, authentic Northwest medicinal materials, and their bacterial fermentation broths. By establishing CRISPR/Cas9 gene-editing systems, we screen for the targets of natural products in specific target cell lines. Combining techniques from molecular biology, cell biology, biochemistry, artificial intelligence, and structural biology, we conduct in-depth studies on the mechanisms of action of natural products at cellular and molecular levels. Utilizing animal models of relevant diseases, we evaluate the therapeutic efficacy and safety of natural products, ultimately developing lead drug molecules.

· Publications

Published Papers:

1. Hyperactivation of HER₂-SHCBP₁-PLK₁ axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer. Wengui Shi, Gengyuan Zhang, Zhijian Ma, Lianshun Li, Miaomiao Liu, Long Qin, Zeyuan Yu, Lei Zhao, Yang Liu, Xue Zhang, Junjie Qin, Huili Ye, Xiangyan Jiang, Huinian Zhou, Hui Sun*, and Zuoyi Jiao*. Nature Communications 2021, 12, 1, 2812.

2. Itaconate is an effector of a Rab GTPasecell-autonomous host defense pathway against Salmonella. Meixin Chen*, Hui Sun*, Maikel Boot, Lin Shao, Shu-Jung Chang, Weiwei Wang, Tukiet T. Lam, Maria Lara-Tejero, E. Hesper Rego, Jorge E. Galán. Science 2020, 369, 450-455.

3. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Zeyuan Yu*, Xiangyan Jiang*, Long Qin, Wen Ren, Haixiao Deng, Jianli Wang, Lei Zhao, Huanxiang Liu, Hong Yan, Hongbin Li, Wengui Shi, Qi Wang, Changjiang Luo, Yan Wang, Juyan Wu, Hui Sun#, and Zuoyi Jiao#. Oncogene 2021, 40, 5, 1027-1042.

4. Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors. Hui Sun, Jana Kamanova, Maria Lara-Tejero, Jorge E. Galan. Nature Microbiology 2018, 3, 10, 1122-1130.

5. A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis. Hui Sun, Jana Kamanova, Maria Lara-Tejero, Jorge E. Galan. PLoS Pathog. 2016, 2, 12, 3.

6. Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Chen H*, Sun H*, You F*, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z. Cell. 2011, 14, 147, 2, 436-46.

7. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z. Nat Immunol. 2009, 10, 12,1300-8.

Patents:

1. Zuoyi Jiao, Zeyuan Yu, Xiangyan Jiang, Hui Sun. Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme E2T. August 5, 2020, China, 202010776754.1

2. Zuoyi Jiao, Qi Wang, Long Qin, Hui Sun, Long Wang, Yan Wang, Junchang Zhang, Zhiliang Yang, Fei Wen, Weiwen Cai. Combination Therapy of Anti-CD87 Antibody and Anti-PD1 Antibody for Gastric Cancer. July 21, 2023, China, ZL202210129119.3

3. Zuoyi Jiao, Qi Wang, Long Qin, Hui Sun, Long Wang, Yan Wang, Junchang Zhang, Zhiliang Yang, Fei Wen, Weiwen Cai. Anti-CD87 Antibody and Its Specific Chimeric Antigen Receptor. June 9, 2023, China, ZL202210129110.2

4. Zuoyi Jiao, Wengui Shi, Long Qin, Zhijian Ma, Gengyuan Zhang, Lianshun Li, Hui Sun. A Novel Combination Method for Treating HER2-Positive Cancers. January 6, 2021, China, 202110015874.4