2004-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授
2000-2004 兰州大学生命科学院、功能有机分子化学国家重点实验室，博士后
1997-2000 兰州大学，理学博士
1994-1997 兰州大学，理学硕士
1989-1993 赣南师范大学，学士
•荣誉奖励
2014 中国环境诱变剂学会活性氧生物学效应专业委员会常务委员
2013 中国生物物理学会自由基生物学与自由基医学分会理事
2006 入选教育部“新世纪优秀人才支持计划”
•研究兴趣
主要研究领域为：自由基化学和自由基生物学、化学生物学、生物有机和药物化学。主要研究兴趣集中于：基于癌细胞的氧化还原特征设计天然产物导向的促氧化抗癌分子。
•代表成果
1. Simultaneous Two-Photon Intravital Imaging of Viscosity and Superoxide Radical Anion by A Styrylpyridinium-Based Fluorescent Probe. Si-Yuan Wang, Jun-Ru Liu, Zheng-Hua Ju, Di-Hua Tian, Zuo-Hu Chai, Yu Zhang, Fang Dai*, Shengxiang Zhang*, and Bo Zhou*, Sens. Actuat. B Chem., 2023, 381, 133470.
2. Engineering Piperlongumine-Inspired Analogs as Nrf2-Dependent Neuroprotectors against Oxidative Damage by an Electrophilicity-Based Strategy. Qi Wang, Dong Lin, Xue-Feng Liu, Fang Dai*, Xiao-Jie Jin*, and Bo Zhou*, Free Radic. Biol. Med., 2023, 194, 298.
3. Tumor Killing by a Dietary Curcumin Mono-Carbonyl Analog that Works as a Selective Ros Generator via Trxr Inhibition. Xuefeng Liu, Hongmei Cui, Mi Li, Zuohu Chai, Haibo Wang, Xiaojie Jin, Fang Dai*, Yongqi Liu*, and Bo Zhou*, Eur. J. Med. Chem., 2023, 250, 115191.
4. Selective Imaging of Hydrogen Peroxide over Peroxynitrite by a Boronate-based Fluorescent Probe Engineered via a Doubly Activated Electrophilicity-Increasing Strategy. Di-Hua Tian†, Jun-Ru Liu†, Si-Yuan Wang, Shuai Yan, Zuo-Hu Chai, Fang Dai*, Shengxiang Zhang*, and Bo Zhou*, Sens. Actuat. B Chem. 2022, 368, 132149.
5. A Coumarin-Based Fluorescent Probe: Small but Multi-Signal. Ya-Long Zheng†, Xiao-Chun Li†, Wei Tang, Li Xie, Fang Dai*, and Bo Zhou*, Sens. Actuat. B Chem. 2022, 368,132169.
6. Prooxidative Inhibition Against NF-κB-Mediated Inflammation by Pharmacological Vitamin C. Yu-Ting Du, Ying Long, Wei Tang, Xue-Feng Liu, Fang Dai, and Bo Zhou*. Free Radic. Biol. Med. 2022, 180, 85.
7. Developing Dietary Curcumin Mono-Carbonyl Piperidinone Analogs as Nrf2-Dependent Cytoprotectors Against Oxidative Damage: Structure-activity Relationship and Mechanisms. Xue-Feng Liu, Qi Wang, Jia-Fang Zheng, Zuo-Hu Chai, Fang Dai*, Xiao-Jie Jin* and Bo Zhou*, Free Radic. Biol. Med. 2022, 186, 66.
8. Michael Acceptor-Dependent Pro-oxidative Intervention against Angiogenesis by [6]-Dehydroshogaol, a Pungent Constituent of Ginger. Xuefeng Liu†, Yihua Wang†, Yalong Zheng, Dechen Duan, Fang Dai, and Bo Zhou*, Eur. J. Pharmacol. 2022, 925, 174990.
9. Developing Push-Pull Hydroxylphenylpolyenylpyridinium Chromophores as Ratiometric Two-Photon Fluorescent Probes for Cellular and Intravital Imaging of Mitochondrial NQO1, Yong-Peng Yang, Fu-Jian Qi, Yi-Ping Qian, Xia-Zhen Bao, Han-Chen Zhang, Bin Ma, Fang Dai*, Sheng-Xiang Zhang*, and Bo Zhou*, Anal. Chem. 2021, 93, 2385-2393.
10. Developing a styrylpyridinium-based fluorescent probe with excellent sensitivity for visualizing basal H2S levels in mitochondria, Bin Ma, Di-Hua Tian, Shuai Yan, Xiao-Chun Li, Fang Dai*, and Bo Zhou*, Sens. Actuat. B Chem. 2021, 327, 128937.
11. A multi-signal mitochondria-targetable fluorescent probe for simultaneously discriminating Cys/Hcy/H2S, GSH, and SO2 and visualizing the endogenous generation of SO2 in living cells, Ya-Long Zheng, Zuo-Hu Chai, Wei Tang, Shuai Yan, Fang Dai*, Bo Zhou*. Sens. Actuat. B Chem. 2021, 330, 129343.
12. Designing an ESIPT-based fluorescent probe for imaging of hydrogen peroxide during the ferroptosis process, Han-Chen Zhang, Di-Hua Tian, Ya-Long Zheng, Fang Dai, Bo Zhou*, Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 248, 119264.
13. A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells. Xiazhen Bao, Qi Wang, Xiaorong Ren, Fang Dai, and Bo Zhou*. Free Radical Bio. Med. 2020, 152, 597-608.
14. Inhibiting NF-κB-Mediated Inflammation by Catechol-Type Diphenylbutadiene via an Intracellular Copper- and Iron-Dependent Pro-Oxidative Role. Fang Dai, Yuting Du, Yalong Zheng, and Bo Zhou*. J. Agr. Food Chem. 2020, 68, 10029-10035.
15. Cooperation of ESIPT and ICT Processes in the Designed 2-(2′-Hydroxyphenyl)benzothiazole Derivative: A Near-Infrared Two-Photon Fluorescent Probe with a Large Stokes Shift for the Detection of Cysteine and Its Application in Biological Environments. Ying Long, Junru Liu, Dihua Tian, Fang Dai*, Shengxiang Zhang*, and Bo Zhou*. Anal. Chem. 2020, 92,14236-14243.
16. A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent. Fang Dai#, Yuting Du#, Yalong Zheng, and Bo Zhou*. Free Radical Bio. Med. 2019, 130, 489-498.
17. Identification of catechol-type ddiphenylbutadiene as a tyrosinase-activated pro-oxidative chemosensitizer against melanoma A375 Cells via glutathione S-transferase inhibition. Yuan Ji, Fang Dai, Shuai Yan, Jingyang Shi, and Bo Zhou*. J. Agr. Food Chem. 2019, 67, 9060-9069.
18. Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs. Xiazhen Bao, Fang Dai, Qi Wang, Xiaoling Jin, and Bo Zhou*, Free Radical Bio. Med. 2019, 134, 406-418.
19. Developing a julolidine-fluorescein-based hybrid as a highly sensitive fluorescent probe for sensing and bioimaging cysteine in living cells. Yuan Ji, Fang Dai, and Bo Zhou*. Talanta 2019, 197, 631-637.
20. Keto-enol-based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells. Fang Dai, Cuihong Yuan, Yuan Ji, Yuting Du, Xiazhen Bao, Lingxi Wu, Xiaoling Jin, and Bo Zhou*. Free Radical Bio. Med. 2018, 120, 124-132.
21. A 1,8-naphthalimide-based turn-on fluorescent probe for imaging mitochondrial hydrogen peroxide in living cells. Fang Dai, Fang Jin, Ying Long, Xiaoling Jin, and Bo Zhou*. Free Radical Res. 2018, 52, 1288-1295.
22. ROS-driven and preferential killing of HepG2 over L-02 cells by a short-term cooperation of Cu(II) and a catechol-type resveratrol analog. Fang Dai, Qi Wang, Guijuan Fan, Yuting Du, and Bo Zhou*. Food Chem. 2018, 250, 213-220.
23. Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone. Xiazhen Bao, Fang Dai, Xinrong Li, and Bo Zhou*. Free Radical Bio. Med. 2018, 124, 342-352.
24. A Catechol-Type Resveratrol Analog Manifests Antiangiogenic Action by Constructing an Efficient Catalytic Redox Cycle with Intracellular Copper Ions and NQO1. Yihua Wang, Fang Dai, and Bo Zhou*. Mol. Nutr. Food Res. 2018, 62, 1700969.
25. Applying an Electrophilicity-Based Strategy to Develop a Novel Nrf2 Activator Inspired from Dietary [6]-Shogaol. Yuting Du, Yalong Zheng, Yuan Ji, Fang Dai*, Yongjing Hu, and Bo Zhou*. J. Agr. Food Chem. 2018, 66, 7983-7994.
26. Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells. Yuan Ji, Fang Dai, and Bo Zhou*. Free Radical Bio. Med. 2018, 129, 215-226.
27. Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals. Fang Dai, Wenjing Yan, Xing Fu, Yalong Zheng, Yuting Du, Xiazhen Bao, Yanfei Kang, Xiaoling Jin, and Bo Zhou*. Eur. J. Med. Chem. 2018, 159, 317-323.
28. Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores. FangDai, WenjingYan, YutingDu, Xiazhen Bao, Xiuzhuang Li, and Bo Zhou*. Free Radical Bio. Med. 2017, 108, 554-563.
29. Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death. Zhishan Tu, Qi Wang, DandanSun, FangDai, and BoZhou*. Eur. J. Med. Chem. 2017, 134, 72-85.
30. Developing piperlongumine-directed glutathione S-transferase inhibitors by an electrophilicity-based strategy. Haibo Wang, Xiaoling Jin, Jiafang Zheng, Fu Wang, FangDai, and BoZhou*. Eur. J. Med. Chem. 2017, 126, 517-525.
31. Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation. WenjingYan, Qi Wang, Cuihong Yuan, Fu Wang, Yuan Ji, Fang Dai, Xiaoling Jin, and BoZhou*. Free Radical Bio. Med. 2016, 97, 109-123.
32. Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. Dong Lin, Fang Dai, Landi Sun, and Bo Zhou*. Mol. Nutr. Food Res. 2015, 59, 2395-2406.
33. Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention. Yan Li, Liping Zhang, Fang Dai, Wenjing Yan, Haibo Wang, Zhihan Tu, and Bo Zhou*. J. Agr. Food Chem. 2015, 63, 7731-7742.
34. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Respons. Tao Shen, Tao Jiang, Min Long, Jun Chen, Dongmei Ren, Pak Kin Wong, Eli Chapman*, Bo Zhou*, and Donna D. Zhang*. Antioxid. Redox Sign. 2015, 23, 651-664.
35. Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids. FangDai, Guoyun Liu, Yan Li, Wenjing Yan, Qi Wang, Jie Yang, Dongliang Lu, Dejun Ding, Dong Lin, and Bo Zhou*. Free Radical Bio. Med. 2015, 85, 127-137.
36. Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent. Landi Sun, Fu Wang, Fang Dai, Yihua Wang, Dong Lin, Bo Zhou*. Biochem. Pharmacol. 2015, 95, 156-169.
37. Tailoring 3,3' -Dihydroxyisorenieratene to Hydroxystilbene: Finding a Resveratrol Analogue with Increased Antiproliferation Activity and Cell Selectivity. Yanfei Kang, Wenjing Yan, Tingwen Zhou, Fang Dai, Xiuzhuang Li, Xiazhen Bao, Yuting Du, Cuihong Yuan, Haibo Wang, Xiaorong Ren, Qiang Liu, Xiaoling Jin, Bo Zhou*, Jie Zhang*. Chem.- Eur. J. 2014, 20, 8904-8908.
Copyrights © All Rights Reserved 版权所有 兰州大学功能有机分子化学国家重点实验室 陇ICP备10000336号
