2023-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授
2016-2022 中南民族大学药学院，教授，院长助理、副院长、国家级实验教学示范中心主任
2001-2015 温州大学，实验师、高级实验师、副研究员，分析测试中心，副主任、主任
2013-2014 南京大学 （合作导师：谭仁祥），博士后
2010-2011 耶鲁大学 （导师：Yinqun Huang）联合培养，研究助理
2007-2012 中国科学院成都生物研究所 (导师: 张安将，丁立生)，理学博士
2005-2007 温州大学 (导师: 张安将，张力学)，理学硕士
1997-2001 中南民族大学，理学学士
·荣誉奖励
2022 中国化学会有机分析专业委员会委员
2022 湖北省高等学校教学成果奖，特等奖（排名第五）
2022 Magnetic Resonance in Chemistry，编委
2022 湖北省晶体学会，理事
2021 核磁共振国际论坛暨新技术研讨会(2021年南京)，会议共同主席
2020 Magnetic Resonance Letters，编委
2020 湖北省药学会，理事
2019 湖北省杰出青年基金资助
2018 黑龙江省技术发明奖，一等奖（排名第六）
2018 Natural Products and Bioprospecting，编委
2014 中德“核磁共振新方法在有机化学中的应用”双边研讨会，发起者和组织者
2014 中国分析测试协会科学技术奖，三等奖
·研究兴趣
核磁共振各向异性参数检测方法及有机分子三维结构测定研究和增敏技术开发；
复杂天然产物的构型鉴定、药物分子的构象分析、有机反应中间体检测及机理研究；
环肽药物噬菌体和mRNA展示技术的开发及其相关酶的定向进化研究；
基于疾病靶标的环肽药物筛选及化学生物学研究。
·代表成果
1. Programmable Alignment Media from Self-Assembled Oligopeptide Amphiphiles for the Measurement of Independent Sets of Residual Dipolar Couplings in Organic Solvents. Lin, Yuexiao; Li, Jiaqian; Qin, Si-Yong; Sun, Han; Yang, Yan-Ling; Navarro-Vazquez, Armando; Lei, Xinxiang*, Chem. Sci., 2022, 13, 5838-5845. Chem Sci Pick of Week, Hot Article Collection, inside back cover.
2. Peptide Probes with High Affinity to Target Protein Selection by Phage Display and Characterization Using Biophysical Approaches. Yang, Xiao-Qin; Bai, Li-Wen; Chen, Yu; Lin, Yue-Xiao; Xiang, Hua; Xiang, Ting-Ting; Zhu, Shuang-Xing; Zhou, Li; Li, Kai*; Lei, Xinxiang*, New J. Chem., 2022, 46, 10299-10307.
3. Ti3C2Tx MXene Liquid Crystal: Access to Create Background-Free and Easy-Made Alignment Medium. Zhao, You; Yu, Qinghua; Cheng, Wei-Wei; Li, Jia-Qian; Zhang, Ai-Qing; Lei, Xinxiang*; Yang, Yingkui; Qin, Si-Yong *, ACS Nano, 2022, 16, 5454-5462.
4. Structural Elucidation of Garcipaucinones A and B From Garcinia paucinervis Using Quantum Chemical Calculations. Tan, Xue; Han, Xiaoyang; Teng, Haida; Li, Qingqing; Chen, Yu; Lei, Xinxiang*; Yang, Guangzhong*, J. Nat. Prod., 2021, 84, 972–978.
5. Solvent-Tailored Ordered Self-Assembly of Oligopeptide Amphiphiles to Create an Anisotropic Meso-matrix. Jiang, Yan; Zhao, You; Zhang, Ai-Qing; Lei, Xinxiang*; Qin, Si-Yong*, Chem. Commun., 2021, 57, 6181-6184.
6. Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid Crystalline Based Medium. Qin, Si-Yong*; Jiang, Yan; Sun, Han; Liu, Han; Zhang, Ai-Qing; Lei, Xinxiang*, Angew. Chem. Int. Ed., 2020, 59, 17097-17103. Hot Paper.
7. Enantioselective Pd-Catalyzed Hydrofluorination of Vinylarenes. Yin, Xuemei; Chen, Bin; Qiu, Feng; Wang, Xihong; Liao, Yang; Wang, Min; Lei, Xinxiang*; Liao, Jian*, ACS Catal., 2020, 10, 1954−1960.
8. Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. Li, Xiao-Lu; Chi, Lu-Ping; Navarro-Vazquez, Armando; Hwang, Songhwan; Schmieder, Peter; Li, Xiao-Ming; Li, Xin; Yang, Sui-Qun; Lei, Xinxiang*; Wang, Bin-Gui*; Sun, Han*, J. Am. Chem. Soc., 2020, 142, 2301−2309.
9. Practical Aspects of Oligopeptide AAKLVFF as an Alignment Medium for the Measurements of Residual Dipolar Coupling of Organic Molecules. Liu, Han; Chen, Pian; Li, Xiao-Lu; Sun, Han; Lei, Xinxiang*, Magn. Reson. Chem., 2020, 58, 404-410.
10. Herpotrichones A and B, Two Intermolecular [4 + 2] Adducts with Anti-Neuroinflammatory Activity from a Herpotrichia Species. Han, Wen-Bo; Wang, Guang-Yi; Tang, Jiang-Jiang; Wang, Wen-Ji; Liu, Han; Gil, Roberto R.; Navarro-Vazquez, Armando; Lei, Xinxiang*; Gao, Jin-Ming*, Org. Lett., 2020, 22, 405−409.
11. Directing an Oligopeptide Amphiphile into an Aligned Nanofiber Matrix for Elucidating Molecular Structures. Qin, Si-Yong*; Ding, Wen-Qiang; Jiang, Zhi-Wei; Lei, Xinxiang*; Zhang, Ai-Qing*, Chem. Commun., 2019, 55, 1659-1662.
12. Enantiomeric NMR Discrimination of Carboxylic Acids Using Actinomycin D as a Chiral Solvating Agent. Bai, Liwen; Chen, Pian; Xiang, Jiangxia; Sun, Jiarui; Lei, Xinxiang*, Org. Biomol. Chem., 2019, 17, 1466-1470.
13. Residual Dipolar Couplings in Structure Determination of Natural Products. Li, Gao-Wei; Liu, Han; Qiu, Feng; Wang, Xiao-Juan; Lei, Xin-Xiang*, Natur. Prod. & Bioprosp., 2018, 8, 279-295.
14. A Self-Assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurement of Residual Dipolar Couplings in Methanol. Lei, Xinxiang*; Qiu, Feng; Sun, Han; Bai, Liwen; Wang, Wen-Xuan; Xiang, Wensheng; Xiao, Hongping, Angew. Chem. Int. Ed., 2017, 56, 12857-12861.
15. Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Li, Gao-Wei; Cao, Jiang-Ming; Zong, Wen; Hu, Li; Hu, Mao-Lin; Lei, Xinxiang*; Sun, Han*; Tan, Ren Xiang*, Chem. Eur. J., 2017, 23, 7653-7656.
16. An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes. Zong, Wen; Li, Gao-Wei; Cao, Jiang-Ming; Lei, Xinxiang*; Hu, Mao-Lin; Sun, Han*; Griesinger, Christian; Tan, Ren Xiang*, Angew. Chem. Int. Ed., 2016, 55, 3690-3693.
17. Enantiodiscrimination of Carboxylic Acids Using the Diphenylprolinol NMR Chiral Solvating Agents. Li, Gaowei; Cao, Jiangming; Zong, Wen; Lei, Xinxiang*; Tan, Renxiang*, Org. Chem. Front., 2016, 3, 96-102.
18. Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents. Lei, Xinxiang*; Xu, Zhen; Sun, Han; Wang, Shun; Griesinger, Christian; Peng, Li; Gao, Chao*; Tan, Ren X*, J. Am. Chem. Soc., 2014, 136, 11280-11283.
19. A Novel Amine Receptor Based on the Binol Scaffold Functions as a Highly Effective Chiral Shift Reagent for Carboxylic Acids. Ma, Qingzhu; Ma, Minshan; Tian, Hongying; Ye, Xiaoxia; Xiao, Hongping; Chen, Lian-hui*; Lei, Xinxiang*, Org. Lett., 2012, 14, 5813-5815.
20. Determinants of mRNA Recognition and Translation Regulation by Lin28. Lei, Xin-Xiang; Xu, Jie; Ma, Wei; Qiao, Chong; Newman, Martin A.; Hammond, Scott M.; Huang, Yingqun*, Nucleic Acids Res., 2012, 40, 3574-3584.
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