张文华

博士、教授

邮箱：

zwh@lzu.edu.cn

网址：

https://lifesc.lzu.edu.cn/teacher_detail.jsp?urltype=tree.TreeTempUrl&wbtreeid=1132&blteacherid=127

·荣誉奖励

2023　　　　　　　兰州大学“萃英学者”特聘教授

2023　　　　　　　甘肃省杰出青年科学基金获得者

·研究兴趣

生物大分子三维结构解析; 大分子构效关系分析; 分子间相互作用分析; 结构酶学; 转运核糖核酸生成与细胞作用; 核酸转录后修饰的生物合成与分子机制

·代表成果

　　1. Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing. Fu W, Lin Y, Bai M, Yao J*, Huang C, Gao L, Mi N, Ma H, Tian L, Yue P, Zhang Y, Zhang J, Ren Y, Ding L, Dai L, Leung J, Yuan J*,  Zhang W*, and Meng W*. Acta Pharmaceutica Sinica B. 2024, 14, 9, 3931e3948.

2. Molecular basis of A. thaliana KEOPS complex in biosynthesizing tRNA t6A. Zheng X, Su C, Duan L, Jin M, Sun Y, Zhu L*,  and Zhang W*. Nucleic Acids Res. 2024, 52, 4523-4540.

3. Characterization of human mitochondrial tRNA t6A-modifying enzyme OSGEPL1. Chen W, Jin M and Zhang W*. SCIENTIA SINICA Vitae 2024, 54, 706-722.

4. Structure-function analysis of an ancient TsaD-TsaC-SUA5-TcdA modular enzyme reveals a prototype of tRNA t6A and ct6A synthetases. Jin M, Zhang Z, Yu Z, Chen W, Wang X, Lei D*, and Zhang W*. Nucleic Acids Res. 2023, 51, 8711-8729.