杨彦龙

博士、副教授、硕士生导师

电话：

+86-17393106147

邮箱：

ylyang@lzu.edu.cn

2017-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室，副教授

2020-2022           德国耶拿大学（导师：Dirk Hoffmeister 教授），博士后

2016-2017           中国科学院微生物研究所，  助理研究员

2013-2016           中国科学院昆明植物研究所，理学博士

2010-2013           中国科学院昆明植物研究所，理学硕士

2006-2010           四川大学，理学学士

•荣誉奖励

2017                    中国科学院优秀博士学位论文

2016                    中国科学院院长优秀奖

2016                    中国科学院优秀毕业生

•研究兴趣

基因组导向的高等真菌中天然产物的发现

高等真菌来源的活性天然产物的生物合成

药用天然产物的合成生物学

•代表成果

1. A Mushroom P450-Monooxygenase Enables Regio- and Stereoselective Biocatalytic Synthesis of Epoxycyclohexenones. Yan-Long Yang, Man Zhou, Lin Yang, Markus Gressler, Johannes Rassbach, Jacob M. Wurlitzer, Ying Zeng, Kun Gao*, and Dirk Hoffmeister, Angew. Chem. Int. Ed. 2023, 62, e202313817.

2. (±)-Pabmaragramin, a scalemic meroterpenoid produced by Marasmius graminum via precursor-assisted biosynthesis. Panlong Ren#, Jing Wang#, Xinyu Miao, Weide Zhu, Yueting Wu, Yun Li, Kun Gao*, Yan-Long Yang*. Tetrahedron Lett. 2021, 63, 152715-152718. 

3. Construction of a meroterpenoid-like compound collection by precursor-assisted biosynthesis. Panlong Ren, Xinyu Miao, Ting Tang, Yueting Wu, Jing Wang, Ying Zeng, Yun Li, Kun Gao *, Yanlong Yang*. Org. Biomol. Chem. 2020, 18, 5850-5856.

4. Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining. Xinlin Li^#, Yuxing Xu^#, Yuan Li, RuiZhang, Tianyuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yanlong Yang*, Wei Gao*. Fungal. Genet. Biol. 2019, 128, 36-42.

5. Clavipines A–C, antiproliferative meroterpenoids with a fused azepine skeleton from the basidiomycete Clitocybe clavipes. Zhaocui Sun, Nailiang Zhu, Man Zhou, Xiaowei Huo, Haifeng Wu, Yu Tian, Junshan Yang, Guoxu Ma*, Yanlong Yang*, and Xudong Xu*. Org. Chem. Front. 2019, 6, 3759-3765.

6. Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis. Yanlong Yang, Yuting Zhang, Shasha Zhang, Qingwen Chen, Ke Ma, Li Bao, Yong Tao, Wenbing Yin, Guodong Wang, and Hongwei Liu. J. Nat. Prod. 2018, 81, 1089-1092.

7. Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Yanlong Yang，Shasha Zhang，Ke Ma，Yuxing Xu，Qiaoqiao Tao，Yihua Chen，Juan Chen，  Shunxing Guo，Jinwei Ren，Wenzhao Wang，Yong Tao，Wenbing Yin, and Hongwei Liu*. Angew. Chem. Int. Ed. 2017, 56, 4749-4752.

8. Recent Advance on Bioactive Compounds from the Edible and Medicinal Fungi in China. Yanlong Yang, Qiaoqiao Tao, Junjie Han, Li Bao, and Hongwei Liu*. 2017, Medicinal Plants and Fungi: Recent Advances in Research and Development  pp 253-312.

9. A monooxygenase from Boreostereum vibrans catalyzes oxidative decarboxylation in a divergent vibralactone biosynthesis pathway. Yanlong Yang, Hui Zhou, Gang Du, Kena Feng, Tao Feng, Xiaoli Fu, Jikai Liu*, and Ying Zeng*. Angew. Chem. Int. Ed. 2016, 55, 5463-5466. 

10. Bioactive Sesquiterpenes from the Edible Mushroom Flammulina velutipes and Their Biosynthetic Pathway Confirmed by Genome Analysis and Chemical Evidence. Qiaoqiao Tao^#, Ke Ma^#, Yanlong Yang^#, Kai Wang, Baosong Chen, Ying Huang, Junjie Han, Li Bao, Xiaobin Liu, Zhuliang Yang, Wenbing Yin, and Hongwei Liu*. J. Org. Chem. 2016, 81, 9867-9877. (#co-first author) 

11. Elucidating the biosynthetic pathway for vibralactone, a novel pancreatic lipase inhibitor with a fused bicyclic β-lactone. Peiji Zhao*, Yanlong Yang, Liangchen Du, Jikai Liu, and Ying Zeng*. Angew. Chem. Int. Ed.  2013, 52, 2298-2302.