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李 云

2018-12-28 10:34:00
李 云
李 云
博士、教授、博士生导师
电话:
+86-931-8911747
邮箱:
liyun@lzu.edu.cn
· EDUCATION AND EXPERIMENCE

2020-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2012-2020           兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授

2009-2012           诺华生物医学研究中心(CNIBR) (导师: 江磊),博士后

2004-2009           中国科学院上海有机化学研究所 (导师: 伍贻康),理学博士

2000-2004           四川大学,工学学士

·荣誉奖励

2020                    德国“Thieme Chemistry Journals Award”

2019                    入选甘肃省“飞天学者特聘计划”青年学者

2019                    亚洲核心计划“ACP Lectureship Award”

•研究兴趣

天然产物全合成,有机合成方法学及药物化学

•代表成果

1. Diastereoselective Ring Expansion of Cyclic Ketones Enabled by Hat-Initiated Radical Cascade. Wenxue Wang, Shouyang Feng, Yansheng Wei, Hongyu Wang, and Yun Li*, Org. Lett. 2023, 25, 8022.

2. Synthetic studies on pseudolaric acid B: Enantioselective synthesis of C4,C10-di-epi-trans-fused [5-7]-bicyclic skeleton. Rui Guo, Hongbin Zhai*, and YunLi*. Chin. Chem. Lett2021, 32, 1400-1402.

3. Enantioselective Total Synthesis of (+)-Arboridinine. Zhang Zhen,  Xie Sujun,  Cheng Bin,  Zhai Hongbin*,  and Li Yun*. J. Am. Chem. Soc2019141, 7147-7154.

4. Facile Synthesis of Pyridines from Propargyl Amines: Concise Total Synthesis of Suaveoline Alkaloids. Zhao Zhiwen, Wei Hongbo, Xiao Ke, Cheng Bin,  Zhai Hongbin, and Li Yun*. Angew. Chem. Int. Ed201958, 1148-1152.

5. Stereoselective Synthesis of Spiro-2-oxabicyclo[2.2.2]octane Enabled by Ag(I)/ Brønsted Acid Relay Catalysis. Zhang Qingyu, Wang Jianping, Wei Yansheng, Zhai Hongbin, and Li Yun*. Org. Lett. 201921, 1694-1698

6. Quick Access to Pyridines through 6π-3-Azatriene Electrocyclization: Concise Total Synthesis of Suaveoline Alkaloids. Wei Hongbo, and Li Yun*. Synlett  201930, 1615-1620. 

7. Relay Catalysis of Rh (II) and Cobaloxime: Stereoselective Synthesis of Spiroindanones from N-Sulfonyl-1,2,3-triazoles. Zhao Liu, Qiuchen Du, Hongbin Zhai, and Yun Li*. Org. Lett201820, 7514-7517.

8. Organocatalytic Synthesis of 4-Aryl-1,2,3,4-tetrahydropyridines from Morita-Baylis-Hillman Carbonates through a One-Pot Three-Component Cyclization. Jian Wei, Yuntong Li, Cheng Tao, Huifei Wang, Bin Cheng, Hongbin Zhai*, and Yun Li*. J. Org. Chem201883, 835-842.

9. The Expanding Utility of Rhodium-Iminocarbenes: Recent Advances in the Synthesis of Natural Products and Related Scaffolds. Yun Li*, Hongjian Yang, and Hongbin Zhai*. Chem.-Eur. J. 201824, 12757-12766. 

10. Bioinspired Total Synthesis of (±)-Chaetophenol C Enabled by a Pd-Catalyzed Cascade Cyclization. Yun Li*, Qingyu Zhang, Hongyu Wang, Bin Cheng, and Hongbin Zhai*. Org. Lett. 201719, 4387-4390.

11. Rhodium-Catalyzed Denitrogenative [3+2] Cycloaddition: Access to Functionalized Hydroindolones and the Framework of Montanine-Type Amaryllidaceae Alkaloids. Hongjian Yang, Shengtai Hou, Cheng Tao, Zhao Liu, Chao Wang, Bin Cheng, Yun Li*, and Hongbin Zhai*. Chem.–Eur. J. 201723, 12930-12936.

12. Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters. Shengtai Hou, Hongjian Yang, Bin Cheng, Hongbin Zhai*, and Yun Li*. Chem. Commun. 201753, 6926-6929.

13.Rh-Catalyzed [3+2] Cycloaddition of 1-Sulfonyl-1,2,3-triazoles: Access to the Framework of Aspidosperma and Kopsia Indole Alkaloids. Yun Li*, Qingyu Zhang, Qiucheng Du, and Hongbin Zhai*. Org. Lett. 201618, 4076-4079.

14. Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy. Hongbo Wei, Yun Li*, Ke Xiao, Bin Cheng, Huifei Wang, Lin Hu, and Hongbin Zhai*. Org. Lett. 201517, 4076-4079.

15.Stereoselective Synthesis of (2Z)-2,4-Dienamides via NBS-Mediated Allyloxyl Addition-Claisen Rearrangement−Dehydrobromination Cascade Reaction of Ynsulfonamides. Runbo Ding, Yun Li*, Cheng Tao, Bin Cheng, and Hongbin Zhai*. Org. Lett. 201517, 3994-3997. 

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