张保新
2020-至今 兰州大学化学化工学院，功能有机分子化学国家重点实验室，副教授
2015-2020 兰州大学化学化工学院，功能有机分子化学国家重点实验室，讲师
2010-2015 兰州大学化学化工学院（导师：房建国 教授），理学博士,
2006-2010 兰州大学化学化工学院，理学学士
•研究兴趣
化学生物学及药物化学
•代表成果
1. Naphthalimide Fluorescent Skeleton for Facile and Accurate Quantification of Glutathione. Fang Zhang, Fan Chen, Ruipeng Shen, Ya-xiong Chen, Zhengjia Zhao, Baoxin Zhang*, and Jianguo Fang*, Anal. Chem., 2023, 95, 4301.
2. Imaging of Carbonic Anhydrase Level in Epilepsy With An Environment-Sensitive Fluorescent Probe. Fang Zhang, Fan Chen, Miao Zhong, Ruipeng Shen, Zhengjia Zhao, Haopai Wei, Baoxin Zhang*, and Jianguo Fang*, Anal. Chem., 2023, 95, 14833.
3. Synthesis and Evaluation of Piperine Analogs as Thioredoxin Reductase Inhibitors to Cause Oxidative Stress-Induced Cancer Cell Apoptosis. Miao Zhong, Lingzhen Chen, Yue Tao, Jintao Zhao, Bingbing Chang, Fang Zhang, Jingwen Tu, Wenqing Cai*, and Baoxin Zhang*, Bioorg. Chem., 2023, 138, 106589.
4. Aloe-Emodin Alleviates Doxorubicin-Induced Cardiotoxicity via Inhibition of Ferroptosis. Ying He, Junmin Xi, Jianguo Fang, Baoxin Zhang*, and Wenqing Cai*, Free Radic. Biol. Med., 2023, 206, 13.
5. Assay of Selenol Species in Biological Samples by the Fluorescent Probe Sel-Green. Baoxin Zhang and Jianguo Fang*, Method. Enzymol. 2022, 662, 259.
6. A Novel off-on Fluorescent Probe for Specific Detection and Imaging of Cysteine in Live Cells and in vivo. Baoxin Zhang, Haijuan Zhang*, Miao Zhong, Song Wanga, Qianhe Xua, Dong-Hyung Cho, and Hongdeng Qiu*. Chinese Chem. Lett. 2020, 31, 133-135.
7. Thioredoxin reductase inhibitors: a patent review. Baoxin Zhang, Junmin Zhang, Shoujiao Peng, Ruijuan Liu, Xinming Li, Yanan Hou, Xiao Han and Jianguo Fang*. Expert. Opin. Ther. Pat. 2017, 27, 547-556.
8. Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications. Baoxin Zhang, Chunpo Ge, Juan Yao, Yaping Liu, Huichen Xie, and Jianguo Fang*. J. Am. Chem. Soc. 2015, 137, 757-769.
9. Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent. Baoxin Zhang, Dongzhu Duan, Chunpo Ge, Juan Yao, Yaping Liu, Xinming Li, and Jianguo Fang*. J. Med. Chem. 2015, 58, 1795-805.
10. Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents. Shoujiao Peng, Baoxin Zhang, Xianke Meng, Juan Yao, and Jianguo Fang. J. Med. Chem. 2015, 58, 5242-5255.
