高 坤
2002-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授
2000-2002 法国巴黎第七大学 (合作导师: 范波涛)，访问学者
1994-1997 兰州大学 (导师: 贾忠建)，理学博士
1985-1989 兰州大学 (导师: 陈耀祖)，理学硕士
1979-1983 兰州大学，理学学士
•荣誉奖励
2009 甘肃省教学成果二等奖（排名第一）
2008 宝钢优秀教师奖
2007 兰州大学“师德标兵”以及“隆基教学名师”
2005 教育部自然科学二等奖（排名第二）
•研究兴趣
主要从事天然产物化学研究，包括：中药和药用植物中天然产物新结构的发现；天然产物活性筛选、结构修饰及药物先导化合物的发现。应用现代分离、分析技术，已从中药、民族药及药用植物中挖掘出了上百种结构新颖的化合物，并在药理实验的指导下，发现数种有意义的生物活性物质及药物先导化合物。近年来在973项目的支持下，从事牧草次生代谢物的研究，取得了较重要的研究结果。
•代表成果
1. Diterpenoids With an Unusual Tricyclo[10.3.0.02,9] Pentadecane Skeleton From Pedilanthus Tithymaloides as Multidrug Resistance Modulators. Lan-Jun Zhang, Pei-Zhi Huang, Ke-Jing Li, Yue-Yang. Cao, Yun Sun, Wei-Jiao Feng, Yu-Xian Wang, Yi-Lin He, Le-Yuan Mi, Yan-Li Wei, Qi-Zhong Lai, Jian-Jun Chen, and Kun Gao*, Bioorg. Chem., 2023, 138, 106619.
2. Anti-Inflammatory Ent-Cleistanthane-Type Diterpenoids from Phyllanthus Rheophyticus. Hong-Ying Yang, Pei-Zhi Huang, Qian Ma, Yun Sun, Wei-Jiao Feng, Yi-Lin He, Jian-Jun Chen*, and Kun Gao*, Phytochemistry, 2023, 212, 113723.
3. Multideuteration of Nitroaromatics by Silver-Catalyzed Hydrogenisotope Exchange. Jianbo Tang, Junhua Kong, Hui Xu, Zhi-Jiang Jiang*, Yifan She, Jianfei Bai, Bencan Tang, Jia Chen, Zhanghua Gao*, and Kun Gao*, J. Org. Chem., 2023, 88, 1560.
4. Triterpenoids and Lignans from Schisandra Chinensis and Their Inhibition Activities of Cdc25A/B Phosphatases. Qian-Qian Zhao, Wen-Jun Wei, Ya Li, and Kun Gao*, Nat. Prod. Res. 2022, 36, 754.
5. Lanthipeptides from the Same Core Sequence: Characterization of a Class II Lanthipeptide Synthetase from Microcystis aeruginosa NIES8. Sha-Sha Zhang, Jiang Xiong, Jiao-Jiao Cui, Kai-Liang Ma, Wen-Liang Wu, Ya Li, Shangwen Luo*, Kun Gao*, and Shi-Hui Dong*, Org. Lett. 2022, 24, 2226.
6. Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas. Yi-Lin He, Pei-Zhi Huang, Hong-Ying Yang, Wei-Jiao Feng, Zhao-Cai Li, and Kun Gao*, Molecules 2022, 27, 3540.
7. Cardiac Glycosides from Digitalis lanata and Their Cytotoxic Activities. Hong-Ying Yang, Ya-Xiong Chen, Shangwen Luo, Yi-Lin He, Wei-Jiao Feng, Yue Sun, Jian-Jun Chen*, and Kun Gao*, RSC Adv. 2022, 12, 23240.
8. Cytotoxic Cardenolides from Calotropis Gigantea. Yi-Lin He, Hong-Ying Yang, Pei-Zhi Huang, Wei-Jiao Feng, and Kun Gao*, Phytochemistry, 2021, 192, 112951.
9. Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus Fortunei. Kai‑Liang Ma, Shi‑Hui Dong, Hang‑Ying Li, Wen‑Jun Wei, Yong‑Qiang Tu, and Kun Gao*, Nat. Product. Bioprosp. 2021, 11, 87–98.
10. Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells. Junmin Zhang, Qianhe Xu, Hong-Ying Yang, Minghao Yang, Jianguo Fang and Kun Gao*, Front. Mol. Biosci. 2021, 8, 710676.
11. Construction of a Meroterpenoid-Like Compound Collection by Precursor-Assisted Biosynthesis. Panlong Ren, Xinyu Miao, Ting Tang, Yueting Wu, Jing Wang, Ying Zeng, Yun Li, Kun Gao*, and Yanlong Yang*. Org. Biomol. Chem. 2020, 18, 5850–5856.
12. Alstonlarsines A−D, Four Rearranged Indole Alkaloids from Alstonia scholaris. XuXin Zhu, Yaoyue Fan, Lei Xu, QunfFang Liu, Jiangping Wu, Jingya Li, Jia Li, Kun Gao*, and Jianmin Yue*. Org. Lett. 2019, 21, 1471−1474.
13. Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica. Zaiqin Zheng, Wenjun Wei, Junmin Zhang, Hangying Li, Kai Xu, Jiayuan Xu, Bencan Tang, Ya Li*, and Kun Gao*. J. Org. Chem. 2019, 84, 4473−4477.
14. Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum. Yi Long, Ting Tang, Li Ying Wang, Bin He,and Kun Gao*. J. Nat. Prod. 2019, 82, 2229−2237.
15. Labdane-Type Diterpenoids from Leonurus japonicus and Their Plant-Growth Regulatory Activity. Hang Ying Li, Xing Peng, Xiaojie Jin, WenJun Wei, KaiLiang Ma, Ya Li, Jianjun Chen*, and Kun Gao*. J. Nat. Prod. 2019, 82, 2568-2579.
16. Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from Abies chensiensis and Their Antibacterial Activity. WenJun Wei, Qiuyan Song, Jingchuan Ying, Hangying Li, Kailiang Ma, Yida Li, Ya Li*, and Kun Gao*. J. Nat. Prod. 2019, 82, 2859−2869.
17. Thiol-inducible and Quick-response DNA Cross-linking Agent. Yuanzhen Xu, Hongbo Wei, Jianjun Chen,and Kun Gao*. Bioorg. Med. Chem. Lett. 2019, 29, 281-283.
18. Anti-inflammatory Evaluation and Structure-Activity Relationships of Diterpenoids Isolated from Euphorbia hylonoma. Wenjun Wei, Weiyan Qi, Xinmei Gao, Kena Feng, Kailiang Ma, Hangying Li, Ya Li*, and Kun Gao*. Bioorg. Chem. 2019, 93, 103256.
19. Kense ring systems and dioxolanone-type secondary metabolites from Phyllosticta capitalensis and their phytotoxic activity. Kailiang Ma, Wenjun Wei, Hang Ying Li, Qiu Yan Song, Shihui Dong,and Kun Gao*. Tetrahedron 2019, 75, 4611-4619.
20. Phytotoxic Diterpenoids from Plants and Microorganisms. Wenjun Wei, Ya Li, Hang Ying Li, Kailiang Ma, Liudi Wang, Kun Gao*. Chem. Biodivers. 2019, 16, e1900398.
21. Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong. Weiyi Zhang, Jinxin Zhao, Li Sheng, Yaoyue Fan, Jingya Li, Kun Gao*, and Jianmin Yue*. Org.Lett. 2018, 20, 4040−4043
22. Quorumolides A-C, Three Cembranoids from Euphorbia antiquorum. Weiyan Qi, Jinxin Zhao, WenjJun Wei, Kun Gao*, Jianmin Yue*. J. Org. Chem. 2018, 83, 1041-1045.
23. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity. Wei Bai, Hongying Yang, Xingzhi Jiao, Kena Feng, Jianjun Chen*, and Kun Gao*. J. Nat. Prod. 2018, 81, 1777−1785.
24. Phytotoxic ent-Isopimarane-Type Diterpenoids from Euphorbia hylonoma. Wenjun Wei, Qiuyan Song, Zaiqin Zheng, Xiaojun Yao, Ya Li*, Kun Gao*. J. Nat. Prod. 2018, 81, 2381-2391.
25. Ligusaginoids A–D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta. Hangying Li, Zaiqin Zheng, Wenjun Wei, Jianjun Chen*, Kun Gao*.Tetrahedron Lett. 2018, 59, 3461–3466
26. Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea europaea L.). Jianteng Wei, Shuxian Wang, Dong Pei, Liangjing Qu, Ya Li, Jianjun Chen, Duolong Di, Kun Gao*. Nat. Prod. Res. 2018, 32, 1967-1970.
27. Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria. Jun Zeng, Dongbo Zhang, Panpan Zhou, Qili Zhang, Lei Zhao, Jianjun Chen*, and Kun Gao*. Org. Lett. 2017, 19, 3998–4001.
28. Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri. Fekadu-Roge Gobu, Jianjun Chen*, Jun Zeng, Wenjun Wei, Weifeng Wang, Changjun Lin, and Kun Gao*. J. Nat. Prod. 2017, 80, 2263-2268.
29. Diterpenoids from Salvia miltiorrhiza and Their Immune-Modulating Activity. Wenjun Wei, Panpan Zhou, Changjun Lin, Weifeng Wang, Ya Li*, and Kun Gao*. J. Agr. Food Chem. 2017, 65, 5985−5993.
30. Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa, A new targeted cytosolic thioredoxin reductase anticancer agent. Meili Yang, Junmin Zhang, Ya Li, Xiao Han, Kun Gao*, and Jianguo Fang*. Arch. Biochem. Biophys. 2016, 607, 20-26.
31. Spirochensilides A and B, Two New Rearranged Triterpenoids from Abies chensiensis. Qianqian Zhao, Qiuyan Song, Kan Jiang, Guangda Li, Wenjun Wei, Ya Li*, and Kun Gao*. Org. Lett. 2015, 17, 2760−2763.
32. Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents. Yuanzhen Xua, XueyanGu, Shoujiao Peng, Jianguo Fang, Yingmei Zhang, Dejun Huang, Jianjun Chen*, and Kun Gao*. Eur. J. Med. Chem. 2015, 94, 284-297.
33. Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy. Yuanzhen Xu, Jianjun Chen, Ya Li, Shoujiao Peng, Xueyan Gu, Meng Sun, Kun Gao*, and Jianguo Fang*. Org. Biomol. Chem. 2015, 13, 2634–2639.
34. Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity. Weiyan Qi, Weiyi Zhang, Yu Shen, Ying Leng, Kun Gao*, and Jianmin Yue*. J. Nat. Prod. 2014, 77, 1452-1458.
35. An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris. Li Zhang, ChunjiangZhang, Dongbo Zhang, Juan Wen, Xiaowei Zhao, Ya Li*, and Kun Gao*.Tetrahedron Lett. 2014, 55, 1815–1817.
36. Synthesis and Structure-Activity Relationships of N-Methyl-5, 6, 7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents. Denggao Zhao, JianJun Chen, Yarong Du, Yanyan Ma, Yaxiong Chen, Kun Gao*, and Burong Hu*. J. Med. Chem. 2013, 56, 1467−1477.
