厍学功
2002-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授
2001-2002 美国俄勒冈大学，博士后
1999-2001 美国科罗拉多州立大学，博士后
1996-1999 兰州大学，理学博士
1993-1996 西北大学，理学硕士
•荣誉奖励
2017 国华杰出学者奖领军人才奖
2016 ACP Lectureship Award
2015 甘肃省自然科学一等奖
2012 甘肃省优秀专家
2011 国家杰出青年基金
2010 药明康德生命化学研究奖
•研究兴趣
1. 具有良好生物活性复杂天然产物的不对称全合成研究
2. 高效、环境友好的有机合成方法学研究
•代表成果
1. Total Synthesis of the Euphorbia Diterpenoid Pepluacetal. Meng Liu, Chuanhua Wu, Xingang Xie,Huilin Li*, and Xuegong She*, Angew. Chem. Int. Ed., 2024, e202400943.
2. Scalable Total Syntheses of (±)-Catellatolactams A and B. Hesi Yang, Yan Zhang, Wei Chen, Hongliang Shi, Liang Huo, Jia Li, Huilin Li, Xingang Xie, and Xuegong She*, Org. Lett., 2023, 25, 1003.
3. Total Syntheses of Phleghenrines A and C: A [4 + 2] Cycloaddition and Ring-Expansion Approach. Hongliang Shi, Huachen Hou, Jinbo Duan, Jinwei Huang, Xiaoguang Duan, Xingang Xie, Huilin Li, and Xuegong She*, Org. Lett., 2023, 25, 3358.
4. Collective Total Syntheses of Five Lycopodium Alkaloids. Feifei He, Shangbiao Feng, Yulong Zhao, Hongliang Shi, Xiaoguang Duan, Huilin Li, Xingang Xie, and Xuegong She*, Angew. Chem. Int. Ed. 2022, 61, e202205439.
5. Ten-Step Total Synthesis of (-)-Andranginine Yulong Zhao, Jiaxin Li, Ruize Ma, Feifei He, Hongliang Shi, Xiaoguang Duan, Huilin Li, Xingang Xie, and Xuegong She*, Org. Lett. 2022, 24, 6880.
6. De Novo Diastereoselective Synthesis of 1-Hydroxyl Allogibberic Methyl Ester en Route to Diverse Bioactive Molecules. Jinyan Chen, Yunxia Yang, Chuanhua Wu, Liang Huo, Xingang Xie, Huilin Li*, and Xuegong She*, Org. Lett. 2022, 24, 6402.
7. Construction of the Skeleton of Lucidumone. Shiqiang Ma, Zhen Li, Pengfei Yu, Hongliang Shi, Hesi Yang, Jiuzhou Yi, Zheng Zhang, Xiaoguang Duan, Xingang Xie, and Xuegong She*, Org. Lett. 2022, 24, 5541.
8. Enantioselective Pictet-Spengler Condensation to Access the Total Synthesis of (+)-Tabertinggine. Dan Long, Gaoyuan Zhao, Zhiqiang Liu, Peiqi Chen, Shiqiang Ma, Xingang Xie, and Xuegong She*, Eur. J. Org. Chem. 2022, 2022, e202200088.
9. Total Synthesis of (+)-Tabertinggine. Dan Long, Zhiqiang Liu, Liang Huo, Hesi Yang, Jiuzhou Yi, Xingang Xie, and Xuegong She*, Tetrahedron 2022, 115, 132781.
10. Brønsted Acid and Lewis Acid Co-promoted Cascade Cyclization Reaction and Application to the Total Synthesis of Erysotramidine. Xiaolin Ju‡, Xiaojun Hu‡, Hongliang Shi, Shiqiang Ma, Feifei He, Xiaolei Wang, Xingang Xie, and Xuegong She*, Org. Chem. Front. 2021, 8, 4839-4844.
11. Rapid Construction of the Tricyclic Core of Annotinine Hydrate. Hongliang Shi, Jinwei Huang, Shiqiang Ma, Xiaolin Ju, Jinbo Duan, Xingang Xie, Xiaolei Wang, and Xuegong She*, Tetrahedron 2021, 82, 131934 .
12. Recent Advances in Total Synthesis of Diquinane-Containing Natural Products. Huilin Li*, Jing Zhang, and Xuegong She*. Chem.-Eur. J. 2021, 39, 795
13. Total Synthesis of (-)-Pepluanol B: Conformational Control of the Eight-Membered Ring System. Jing Zhang, Meng Liu, Chuanhua Wu, Gaoyuan Zhao, Peiqi Chen, Lin Zhou, Xingang Xie, Ran Fang, Huilin Li*, and Xuegong She*. Angew. Chem. Int. Ed. 2020, 59, 3966-3970.
14. Total Synthesis of (−)-Gardmultimine A. Peiqi Chen, Hesi Yang, Hao Zhang, Wei Chen, Zheng Zhang, Jing Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Lett. 2020, 22, 2022–2025.
15. A Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation. Hao Zhang, Peiqi Chen, Hesi Yang, Shiqiang Ma, Zemin Wang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem. 2020, 85, 3954–3962.
16. Synthesis of 2,3-disubstituted indoles via a tandem reaction. Shiqiang Ma, Dan Long, Peiqi Chen, Hongliang Shi, Huilin Li, Ran Fang, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front. 2020, 7, 2689-2695.
17. A copper-catalyzed radical coupling/fragmentation reaction: efficient access to β-oxophosphine oxides. Shangbiao Feng, Jinlai Li, Feifei He, Tao Li, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front. 2019, 6, 946-951.
18. A concise approach to the tricyclic framework of longipinane- and ent-longipinane-type sesquiterpenoids. Min He, Jiuzhou Yi, Gaoyuan Zhao, Peiqi Chen, Dan Long, Xiaojun Hu, Huilin Li,Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Chem. Front. 2019, 6, 383-387.
19. Total Synthesis of Aspidofractinine Alkaloid Paucidirinine. Weiwei Zhang, Shanhao Lin, Chenglong Du, Shangbiao Feng, Zaimin Liu, Jing Zhang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem. 2019, 84, 1111-1116.
20. Asymmetric Total Synthesis of (+)-Winchinine B. Zaimin Liu, Xiaolin Ju, Shiqiang Ma, Chenglong Du, Weiwei Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. J. Org. Chem. 2019, 84, 14994-15000.
21. Construction of the Tetracyclic Core of Calyciphylline B‑Type Daphniphyllum Alkaloids. Chenglong Du, Jing Fang, Jinyan Chen, Zaimin Liu, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*, Org. Lett. 2019, 21, 8718−8721.
22. Bioinspired total synthesis of (−)-gymnothelignan L. Peng Chen, Liang Huo, Huilin Li, Lin Liu, Ziyun Yuan, Hao Zhang, Shangbiao Feng, Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Chem. Front. 2018, 5, 1124.
23. Total synthesis of conosilane A via a site-selective C–H functionalization strategy. Ziyun Yuan, Xiaojun Hu, Hao Zhang, Lin Liu, Peng Chen, Min He, Xingang Xie, Xiaolei Wang, and Xuegong She*. Chem. Commun. 2018, 54, 912-915.
24. Palladium-Promoted Neutral 1,4-Brook Rearrangement/Intra- molecular Allylic Cyclization Cascade Reaction: A Strategy for the Construction of Vinyl Cyclobutanols. Hao Zhang, Shiqiang Ma, Ziyun Yuan, Peng Chen, Xingang Xie, Xiaolei Wang, and Xuegong She*, Org. Lett. 2017, 19, 3478-3481.
25. (3+2)-Annulation of p‑Quinamine and Aryne: A Strategy To Construct the Multisubstituted Hydrocarbazoles. Dengyu Xu, Yulong Zhao, Dengpeng Song, Zhuliang Zhong, Shangbiao Feng, Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Lett. 2017, 19, 3600−3603.
26. Visible-light-mediated radical insertion/cyclization cascade reaction: synthesis of phenanthridines and isoquinolines from isocyanides. Shangbiao Feng, Tao Li, Chenglong Du, Peng Chen, Dengpeng Song, Jinlai Li, Xingang Xie, and Xuegong She*. Chem. Commun. 2017, 53, 4585-4588.
27. Bioinspired Collective Syntheses of Iboga-Type Indole Alkaloids. Gaoyuan Zhao, Xingang Xie, Haiyu Sun, Ziyun Yuan, Zhuliang Zhong, Shouchu Tang, and Xuegong She*. Org. Lett. 2016, 18, 2447-2450.
28. Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B. Dengpeng Song, Zhengshen Wang, Ruoming Mei, Weiwei Zhang, Donghui Ma, Dengyu Xu, Xingang Xie, and Xuegong She*. Org. Lett. 2016, 18, 669-671.
29. Protecting-Group-Free Total Synthesis of (−)-Lycopodine via Phosphoric Acid Promoted Alkyne Aza-Prins Cyclization. Donghui Ma, Zhuliang Zhong, Zaimin Liu, Mingjie Zhang, Shiyan Xu, Dengyu Xu, Dengpeng Song, Xingang Xie, and Xuegong She*. Org. Lett. 2016, 18, 4328−4331.
30. Gold-Catalyzed 1, 2-Acyloxy Migration/Intramolecular [3+2] 1, 3-Dipolar Cycloaddtion Cascade Reaction: An Efficient Strategy for Syntheses of Medium-Sized-Ring Ethers and Amines. Changgui Zhao, Xingang Xie, Shuangshuang Duan, Huilin Li, Ran Fang, and Xuegong She*. Angew. Chem. Int. Ed. 2014, 53, 10789-10793.
31. N‑Heterocyclic Carbene-Catalyzed Formal [3+2] Annulation of Alkynyl Aldehydes with Nitrosobenzenes: A Highly Regioselective Umpolung Strategy. Runfeng Han, Jing Qi, Jixiang Gu, Donghui Ma, Xingang Xie, and Xuegong She*. ACS Catal. 2013, 3, 2705-2709.
32. Pt-Catalyzed Tandem 1, 2-Acyloxy Migration/Intramolecular [3+2] Cycloaddition of Enynyl Esters. Huaiji Zheng, Jiyue Zheng, Binxun Yu, Qiang Chen, Xiaolei Wang, Yongping He, Zhen Yang, and Xuegong She*. J. Am. Chem. Soc. 2010, 132, 1788–1789.
