王晓磊
2017.03-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授
2015.04-2017.02 The Scripps Research Institute (合作导师: Chi-Huey Wong)，研究助理
2011.07-2015.03 UT Southwestern Medical Center (合作导师: Chuo Chen)，博士后
2006.09-2011.06 兰州大学化学系(导师：厍学功)，有机化学博士
2002.09-2006.07 兰州大学化学基地班，学士学位
•研究兴趣
研究方向：功能性糖全合成、方法学及新型靶点抗生素、免疫抑制剂药物研发以及相关通路研究。
•代表成果
1. Bioinspired Total Synthesis of Complex Nucleoside Antibiotics A201A, A201D and A201E. Wang, J.; Gao, J.; Guo, T.; Huo, X.; Zhang, W.; Liu, J.; Wang, X.*Angew. Chem. Int. Ed., 2023, 62, e202213810.
2. Synthesis of the Disaccharide Core of Ezomycin Nucleosides. Shuai Fan, Tai Jiang, Tinghong Lv, Jian Liu, and Xiaolei Wang*, Org. Lett., 2023, 25, 4355.
3. Total Synthesis of Nikkomycin Sz and Nikkomycin Soz. Shuai Fan, Tai Jiang, Muhammad Nasir Siddique, Lei Zhang, Jian Liu, and Xiaolei Wang*, Org. Lett., 2023, 25, 7832.
4. Highly Diastereoselective Synthesis of C‑Glycosides from Glycal Anomers. Lisi Yuan, Ya Fang, Zhaobo Zhou, Tinghong Lv, Yingpeng Su, Jian Liu, and Xiaolei Wang*, Org. Lett., 2023, 25, 4394.
5. Total Synthesis of Complex Peptidyl Nucleoside Antibiotics: Asymmetric De Novo Syntheses of Miharamycin B and Its Biosynthetic Precursor. Huang, W.; Fan, S.; Mao, J.; Luo, S.; Tang, S.; Liu, J.*; Wang, X.* Angew. Chem. Int. Ed., 2022, 61, e202204907.
6. Enzyme-like C–H Oxidation of Glucosides Promoted by Visible Light. Wu, M.; Jiang, Q.; Tian, Q.; Guo, T.; Cai, F.; Tang, S.; Liu, J. *; Wang, X.*CCS Chem. 2022, 4, 3599–3608.
7. Generation of Fused Seven-Membered Polycyclic Systems via Ring Expansion and Application to the Total Synthesis of Sesquiterpenoids.Xing, Z.; Fang, B.; Luo, S.; Xie, X.; Wang, X.* Org. Lett. 2022, 24, 4034–4039.
8. Site-Selective C–H Alkylation of Myo-Inositol via Organic Photoredox Catalysis.Cao, H.; Guo, T.; Deng, X.; Huo, X.; Tang, S.; Liu, J.*; Wang, X.* Chem. Commun., 2022, 58, 9934-9937.
9. Nonenzymatic Asparagine Motif Synthesis by Photoredox-Catalyzed Carbamoylation of Dehydroalanine. Guo, T.; Wang, H.; Wang, C.; Tang, S.; Liu, J. *; Wang, X.*J. Org. Chem. 2022, 87, 6852–6859.
10. Stereodivergent Synthesis of C-Glycosamino Acids via Pd/Cu Dual Catalysis. Yan, X.; Feng, F.; Zhou, L.; Chen, L.; Tang, S.; Liu, J.; Cai, F.; Wang, X. *.Science China Chemistry. 2021, 64, 552-557.
11. Palladium Catalyzed Reductive Heck Coupling and its Application in Total Synthesis of (-)-17-nor-Excelsinidine. Yuan LS.; Chen LR.; Yan XX.; Gao K*.; Wang XL*, RSC Adv. 2021, 11, 757.
12. Enantioselective α Functionalization of 1,3-Dithianes by Iridium-Catalyzed Allylic Substitution. Wang, P.P.；Jiang, Q.; Zhao, R.B.; Xie, X.G.;* Tang, S.C*.; Wang, X.L*, J. Org. Chem. 2020, 85, 12456−12467.
13. Dithiane-Induced [3+2] Cycloaddition Tactic for the Convergent Synthesis of Dihydropyrrole and Pyrrole Derivatives. Jia, H.B.; Min, D.; Guo, T.Y.; Wu, M.Z.; Wang, X.L*.; Liu, J*.; Tang SC*. J. Org. Chem. 2020, 85, 14847−14857.
14. Visible-light Promoted Dithioacetalization of Aldehydes with Thiols under Aerobic and Photocatalyst-free Conditions. Xing, Z.; Yang, M.; Sun, H.; Wang, Z.; Chen, P.; Liu, L.; Wang, X. * Xie, X.*.; She, X., Green Chem. 2018, 20, 5117.
15. Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence. Ma, Z.; Wang, X.; Wang, X.; Gao, S.; Tan, X.; Ma, Y.; Lynch, V. M.; Chen, C. Science (Co-first auhor,Highlighted in C&EN News) 2014, 346, 219.
16. The Development of Highly Potent Inhibitors for Porcupine. Wang, X.; Moon, J.; Dodge, M.; Pan, X.; Zhang, L.; Hanson, J.; Tuladhar, R.; Ma, Z.; Shi, H.; Williams, N.; Amatruda, J.; Carroll, T.; Lum, L.; Chen, C. J. Med. Chem. 2013, 56, 2700–2704.
