杨尚东
2009-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授
2007-2009 芝加哥大学化学系 (导师: 何川)，博士后
2006-2007 北京大学 (导师: 施章杰)，博士后
2003-2006 兰州大学 (导师: 梁永民)，理学博士
1997-2003 甘肃电力科学研究院工作，工程师
1993-1997 兰州大学，理学学士
•荣誉奖励
2015 Thieme Chemistry Journal Award奖
2013 中国百篇最具影响国际学术论文奖
2013 国家自然科学二等奖（排名第四）
•研究兴趣
有机磷化学，不对称合成
•代表成果
1. Electrophilic Selenium-Catalyzed Desymmetrizing Cyclization to Access P-Stereogenic Heterocycles. Zhi-Chao Qi, Yuke Li, Juan Wang, Lan Ma, Gang-Wei Wang, and Shang-Dong Yang*, ACS Catal. 2023, 13, 13301.
2. Nickel-Catalyzed Kinetic Resolution to Achieve P-Chiral Phosphine Oxides and Sec-Phosphine Oxides. Xi Zhang, Shao-Qiu Wang, and Shang-Dong Yang*, Sci. China Chem. 2023, 66, 2569.
3. Phosphine Oxide Directing-Group-Enabled Atroposelective C–H Bond Acyloxylation via an Eight-Membered Palladacycle Intermediate. Peng-Bo Bai, Ming-Ying Wu, Xin-Xin Yang, Gang-Wei Wang, and Shang-Dong Yang*, Chin. Chem. Lett. 2023, 34, 107894.
4. Nickel-Catalyzed Sodium Hypophosphite-Participated Direct Hydrophosphonylation of Alkyne toward H‑Phosphinates. Dang-Wei Qian, Jin Yang, Gang-Wei Wang, and Shang-Dong Yang*, J. Org. Chem. 2023, 88, 3539.
5. Palladium-Catalyzed Relay C-H Functionalization to Construct Novel Hybrid-Arylcyclophosphorus Ligand Precursors. Juan Wang, Peng-Bo Bai, and Shang-Dong Yang*, Chin. Chem. Lett. 2022, 33, 2397.
6. Lewis Acid-Catalyzed Pudovik Reaction-Phospha-Brook Rearrangement Sequence to Access Phosphoric Esters. Jin Yang, Dang-Wei Qian, and Shang-Dong Yang*, Beilstein J. Org. Chem. 2022, 18, 1188.
7. Temporary (PQO) directing group enabled carbazole ortho arylation via palladium catalysis, Zhi-Chao Qi, Qin-Xin Lou, Yuan Niu and Shang-Dong Yang*, Chem. Commun. 2021, 57, 2021-2024
8. Visible-light-facilitated P-center radical addition to CQX (X = C, N) bonds results in cyclizations. Chong Li, Juan Wang and Shangdong Yang*, Chem. Commun. 2021, 57, 7997-8002.
9. Heck Reaction Boosted Heterocycle Ring-Closing and Ring-Opening Rearrangement: A Strategy for the Synthesis of Indolyl-Type Ligands. Chong Li, Zhi-Chao Qi, Jing-Yu Li and Shangdong Yang*, J. Org. Chem. 2021, 86, 16977-16991.
10. The sequential C–H oxidation/asymmetric phosphonylation of primary alcohols to synthesize α-hydroxy phosphonates, Shifu Ying, Xiaoling Huang, Xinwei Guo and Shang-Dong Yang*, Green Synth. and Catal. 2021, 2, 315-319.
11. Enantioselective Cobalt-Catalyzed Reductive Cross-Coupling for theSynthesis of Axially Chiral Phosphine-Olefin Ligands, Xi Zhang, Juan Wang and Shang-Dong Yang*, ACS Catal. 2021, 11, 14008-14015.
12. New Staudinger Strategy Enabled N-Acyl Phosphinamidites Synthesis, Yuan-Yuan Zhu, Gang-Wei Wang, Jin Yang and Shang-Dong Yang*, CCS Chem., 2021, 3, 1702-1709.
13. Concise synthesis of N-phosphorylated amides through three-component reactions, Yuan-Yuan Zhu, Tao Zhang, Linlin Zhou and Shangdong Yang*, Green Chem. 2021, 23, 9417-9421.
14. Recent advances in the synthesis and applications of phosphoramides, Y Yuan-Yuan Zhu, Yuan Niu, Yan-Ning Niu and Shangdong Yang*, Org. Biomol. Chem. 2021, 19, 10296-10313.
15. Iridium(III)-Catalyzed C-H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives, Qin-Xin Lou, Jing-Yu Li and Shangdong Yang*, Synlett, 2021, 32, 1365-1370.
16. Recent advances in radical phosphorylation, Yuan Niu and Shangdong Yang*, Chem. Synth. 2021, 1, 12-14.
17. Ir(III)-Catalyzed C−H Functionalization of Triphenylphosphine Oxide toward 3‑Aryl Oxindoles. Qinxin Lou, Yuan Niu, Zhichao Qi, and Shangdong Yang*. J. Org. Chem. 2020, 85, 14527-14536.
18. Copper-catalyzed arylation of polycyclic aromatic hydrocarbons by the P=O group. Yuan Niu, Zhichao Qi, Qinxin Lou, Pengbo Bai, and Shangdong Yang*. Chem. Commun. 2020, 56, 14721-14724.
19. Diastereoselective Synthesis of P-Chirogenic and Atropisomeric 2,2'-Bisphosphino-1,1'-binaphthyls Enabled by Internal Phosphine Oxide Directing Groups. Chong Li, and Shangdong Yang*. Chinese J. Org. Chem. 2020, 40, 2159-2160.
20. Bismuth(III)-Catalyzed Sequential Enamine-Imine Tautomerism/2-Aza-Cope Rearrangement of Stable β-Enaminophosphonates: One-Pot Synthesis of β-Aminophosphonates. Ming Jin, Shifu Yin, Shangdong Yang*. Org. Lett. 2020, 22, 2811-2815.
21.Generation of a Key Synthon of Indole Alkaloid Synthesis by Palladium(II)-Catalyzed Indole 2-Methylenephosphorylation. Yuan Niu, Pengbo Bai, Qinxin Lou, and Shangdong Yang*. ChemCatChem 2020, 12, 3644-3649.
22. Allylation of β-amino phosphonic acid precursor via palladium-NHC catalyzed allylic C-H activation. Wei Ren, Ming Jin, QianmingZuo, and Shangdong Yang*. Org. Chem. Front. 2020, 7, 298-302.
23. Photo-induced phosphorus radical involved semipinacol rearrangement reaction: Highly synthesis of γ-oxo-phosphonates. Chunhai Wang, Xiaoling Huang, Xueting Liu, Suqian Gao, Bin Zhao, and Shangdong Yang*. Chinese Chem. Lett. 2020, 31, 677-680.
24. Pd-Catalyzed Heck-Type Reaction: Synthesizing Highly Diastereoselective and Multiple Aryl-Substituted P‑Ligands. Chong Li, Xiaoyue Qiang, Zhichao Qi, Bin Cao, Jingyu Li, and Shangdong Yang*. Org. Lett. 2019, 21, 7138-7142.
25. Visible photocatalysis of novel oxime phosphonates: synthesis of β-aminophosphonates. Yonghong Li, Chunhai Wang, Suqian Gao, Fengming Qi, and Shangdong Yang*. Chem. Commun. 2019, 55, 11888-11891.
26. Palladium-NHC-Catalyzed Allylic Alkylation of Pronucleophiles with Alkynes. Wei Ren, Qianming Zuo, Yanning Niu, and Shangdong Yang*. Org. Lett. 2019, 21, 7956-7960.
27. Applications of transition metal catalyzed P-radical for synthesis of organophosphorus compounds. Wei Ren, Qiang Yang, and Shangdong Yang*. Pure Appl. Chem. 2019, 91, 87-94.
28. NHCs-Catalyzed the Synthesis of Benzazole-Phoshpine Ligands under Air Condition. Wei Ren, Qianming Zuo, and Shangdong Yang*. Synlett 2019, 30, 1719-1724.
29. Visible-light-induced tandem phosphorylation cyclization of vinyl azides under mild conditions. Yonghong Li, Yuanyuan Zhu , and Shangdong Yang*. Org. Chem. Front. 2018, 5, 822-826.
30. Rh(III)-Catalyzed Phosphine Oxide Migration Reactions: Selective Synthesis of 3-Phosphinoylindoles. Chunhai Wang, and Shangdong Yang*. Chem-Asian J. 2018, 13, 2401-2404.
31. Autoxidation Photoredox Catalysis for the Synthesis of 2‑Phosphinoylindoles. Chunhai Wang, Yonghong Li, and Shangdong Yang*. Org. Lett. 2018, 20, 2382-2385.
32. Visible-Light-Catalyzed Phosphonation-Annulation: An Efficient Strategyto Synthesize β-Phosphonopyrrolidines and β-Phosphonolactones. Chong Li, Zhichao Qi, Qiang Yang, Xiaoyue Qiang, and Shangdong Yang*. Chinese J. Chem. 2018, 36, 1052-1058.
33. Direct Allylic C(sp3)‑H Alkylation with 2‑Naphthols via Cooperative Palladium and Copper Catalysis: Construction of Cyclohexadienones with Quaternary Carbon Centers. Ming Jin, Wei Ren, Dangwei Qian, and Shangdong Yang*. Org. Lett. 2018, 20, 7015-7019.
34. Photocatalyzed Intermolecular Aminodifluoromethylphosphonation of Alkenes: Facile Synthesis of a,a-Difluoro-g-aminophosphonates. Qiang Yang, Chong Li, Zhichao Qi, Xiaoyue Qiang, and Shangdong Yang*, Chem.-Eur. J. 2018, 24, 14363-14367.
35. New Approaches for Biaryl-Based Phosphine Ligand Synthesis via P=O Directed C−H Functionalizations. Yanna Ma, Shixia Li, and Shangdong Yang*. Acc. Chem. Res. 2017, 50, 1480-1492.
36. Highly Efficient and Divergent Construction of Chiral γ‑Phosphono-α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated C(sp3)−H Bonds. Qiang Yang, and Shangdong Yang*. ACS Catal. 2017, 7, 5220-5224.
37. Direct Allylic C−H Bond Activation To Synthesize [Pd(η3‑cin)(IPr)Cl] Complex: Application in the Allylation of Oxindoles. Rongbin Hu, Chunhai Wang, Wei Ren, Zhong Liu, and Shangdong Yang*. ACS Catal. 2017, 7, 7400-7404.
38. Diastereoselective Radical Oxidative C−H Aminations toward Chiral Atropoisomeric (P,N) Ligand Precursors. Yanna Ma, Mingxing Cheng, and Shangdong Yang*. Org. Lett. 2017, 19, 600-603.
39. Palladium-Catalyzed Migratory Insertion of Isocyanides for Synthesis of C‑Phosphonoketenimines. Qiang Yang, Chong Li, Mingxing Cheng, and Shangdong Yang*. ACS Catal. 2016, 6, 4715-4719.
40. Enantioselective synthesis of arylglycine derivatives by direct C–H oxidative cross-coupling. Xiaohong Wei, Gangwei Wang, and Shangdong Yang*. Chem. Commun. 2015, 51, 832-835.
41. A unique Copper-catalyzed Cross-coupling Reaction by Hydrogen (H2) Removal for the Stereoselective Synthesis of 3-phosphoindoles. Anxi Zhou, Liuliang Mao, Gangwei Wang, and Shangdong Yang*. Chem. Commun. 2014, 50, 8529-8532.
42. Regio- and Stereoselective Allylic C−H Arylation with Electron-Deficient Arenes by 1, 1′-Bi-2-naphthol−Palladium Cooperation. Gangwei Wang, Anxi Zhou, Shixia Li, and Shangdong Yang*. Org. Lett. 2014, 16, 3118-3121.
43. Direct Annulations toward Phosphorylated Oxindoles by Silver-Catalyzed Carbon-phosphorus Functionalization of Alkenes. Yamin Li, Meng Sun, Hongli Wang, Qiuping Tian, and Shangdong Yang*. Angew. Chem. Int. Ed. 2013, 52, 3972-3976.
