Wenhua Zhang
· Honors And Awards
2023 Lanzhou University “Cuiying Scholar”Professorship
2023 Gansu Province Natural Science Funds for Distinguished Young Scholar
· Research Topics
Structural determination of macromolecules, analysis of structure-function relationship, characterization of intermolecular interactions, structural enzymology, biogenesis of transfer RNA and cellular roles, biosynthesis of post-transcriptional modifications and molecular mechanisms
· Publications
1. Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing. Fu W, Lin Y, Bai M, Yao J*, Huang C, Gao L, Mi N, Ma H, Tian L, Yue P, Zhang Y, Zhang J, Ren Y, Ding L, Dai L, Leung J, Yuan J*, Zhang W*, and Meng W*. Acta Pharmaceutica Sinica B. 2024, 14, 9, 3931e3948.
2. Molecular basis of A. thaliana KEOPS complex in biosynthesizing tRNA t6A. Zheng X, Su C, Duan L, Jin M, Sun Y, Zhu L*, and Zhang W*. Nucleic Acids Res. 2024, 52, 4523-4540.
3. Characterization of human mitochondrial tRNA t6A-modifying enzyme OSGEPL1. Chen W, Jin M and Zhang W*. SCIENTIA SINICA Vitae 2024, 54, 706-722.
4. Structure-function analysis of an ancient TsaD-TsaC-SUA5-TcdA modular enzyme reveals a prototype of tRNA t6A and ct6A synthetases. Jin M, Zhang Z, Yu Z, Chen W, Wang X, Lei D*, and Zhang W*. Nucleic Acids Res. 2023, 51, 8711-8729.
