Ya Li
2009-Present College of Chemistry and Chemical Engineering, State Key Laboratory of
Applied Organic Chemistry, Lanzhou University，Associate professor
2017-2018 Texas Tech University (Advisor: W. David Nes), Visiting scholar
2009-2010 University of Missouri (Advisor: Kent S. Gates), Visiting scholar
2005-2009 College of Chemistry and Chemical Engineering, State Key Laboratory of
Applied Organic Chemistry, Lanzhou University，Lecturer
2005-2002 Lanzhou Institute of Chemical Physics (Advisor: Yanping Shi), D.Sc
1999-2002 Lanzhou University (Advisor: Yu Li), M.Sc
1995-1999 Lanzhou University, B.Sc
· Research Topics
Natural Product Chemistry and Mechanisms of Enzyme Inactivation: Historically, structurally unusual natural products possess potent biological activity, and because of their potent bioactivity, natural products represent a rich source of pharmaceuticals. In fact, it has recently been estimated that more than 60% of the anti-infective and anticancer agents in current use or in advanced clinical trials are derived from natural products.
We focus on the natural products possessing potent biological activity, particular those isolated from Chinese traditional medicinal plant resources. We are currently investigating the fundamental chemical and enzymatic reactions underlying the regulation of nitric oxide synthase with small molecules isolated from plant resources.
· Publications
1. Structurally Diverse Diterpenoids from the Roots of Euphorbia Fischeriana Steud. Ya Li, Xingzhi Jiao, Tinghong Lv, Meili Yang, and Kun Gao*, Fitoterapia 2022, 162, 105296.
2. New Acylglycosides from the Roots of Rheum palmatum L. Wei-Jiao Feng, Hong-Ying Yang, Yi-Lin He, Ya Li*, and Kun Gao*, Phytochem. Lett. 2022, 49, 83.
3. Isolation, Identification, and Activity Evaluation of Diterpenoid Alkaloids from Aconitum Sinomontanum. Ya Li*, Jun Zeng, Yu-hua Tian, Yanan Hou, Honghong Da, Jianguo Fang, Kun Gao*, Phytochemistry 2021, 190, 112880.
4. Chemical Structures of Lignans and Neolignans Isolated from Lauraceae. Ya Li*, Shuhan Xie, Jinchuan Ying, Wenjun Wei, and Kun Gao*. Molecules 2018, 23, 3164.
5.Phytotoxic ent-Isopimarane-Type Diterpenoids from Euphorbia hylonoma. Wenjun Wei, Qiuyan Song, Zaiqin Zheng, Xiaojun Yao, Ya Li*, and Kun Gao*. J. Nat. Prod. 2018, 81, 2381-2391.
6. Antifungal Activities of Isoflavonoids from Uromyces striatus Infected Alfalfa. Ya Li, Guangda Li, Hitao Yu, Xingzhi Jiao, and Kun Gao*.Chem. Biodivers. 2018, 15, e1800407.
7. Diterpenoids from Salvia miltiorrhiza and their immune-modulating activity. Wenjun Wei, Panpan Zhou, Changjun Lin, Weifeng Wang, Ya Li*, and Kun Gao*. J. Agr. Food Chem. 2017, 65, 5985−5993.
8. Aphapolins A and B: Two Nemoralisin Diterpenoids Isolated from Aphanamixis polystachya (Wall.) Fuhu Fang, Wenjun Huang, Shuangyan Zhou, Zhengzhi Han, Manyu Li, Lifang Liu, Xiaozhen Wu, Xiaojun Yao, Ya Li*, and Chengshan Yuan*. Eur. J. Org. Chem. 2017, 4429-4433.
9. Spirochensilides A and B, two new rearranged triterpenoids from Abies chensiensis. Qianqian Zhao, Qiuyan Song, Kan Jiang, Guangda Li, Wenjun Wei, Ya Li*, and Kun Gao*. Org. Lett. 2015, 17, 2760-2763.
10. New lignans from the roots of Schisandra sphenanthera. Kan Jiang, Qiuyan Song, Shoujiao Peng, Qianqian Zhao, Guangda Li, Ya Li*, and Kun Gao*. Fitoterapia 2015, 103, 63-70.
11. Inactivation of Protein Tyrosine Phosphatases by Dietary Isothiocyanates. Sarah M.Lewis, Ya Li, Michael J. Catalano, Adrian R.Laciak, HarkewalSingh, Derrick R.Seiner, Thomas J.Reilly, John J.Tanner, and Kent S.Gates*. Bioorg. Med. Chem. Lett. 2015, 25, 4549–4552.
12. Thiophene acetylenes and furanosesquiterpenes from Xanthopappus subacaulis and their antibacterial activities. Li Zhang, Chaojun Chen, Jia Chen, Qianqian Zhao, Ya Li*, and Kun Gao*. Phytochemistry 2014, 106, 134-140.
13. An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris. Li Zhang, Chunjiang Zhang, Dongbo Zhang, Juan Wen, Xiaowei Zhao, Ya Li*, and Kun Gao*. Tetrahedron Lett. 2014, 55, 1815-1817.
14. Trinorsesquiterpenoids from Inula racemose. Yanyan Ma, Denggao Zhao, Ying Zhai, Ya Li*, and Kun Gao*. Phytochemistry Lett. 2013, 6, 645-648.
