Yanlong Yang
2017－2018 College of chemistry and Chemical Engineering, Lanzhou University,
State Key Laboratory of Applied Organic Chemistry, Associate professor
2020 - 2022 Jena University (Professor Dirk Hoffmeister) , Germany, Postdoctoral
2016－2017 Institute of Microbiology, Chinese Academy of Science, Assistant professor
2013－2016 Kunming Institute of Botany, Chinese Academy of Sciences, Ph.D.
2010－2013 Kunming Institute of Botany, Chinese Academy of Sciences, M.S.
2006－2010 Sichuan University, B.S.
· Honors and Rewards
2017 Excellent Doctoral Dissertation of Chinese Academy of Sciences
2016 Dean of Chinese Academy of Sciences Excellence Award
2016 Outstanding graduates of Chinese Academy of Sciences
· Research Topics
Biochemical and genetic basis of higher fungal natural product biosynthesis
Research in our lab focuses on elucidating the biosynthetic pathway of important natural products especially for diterpenoids and meroterpenoids from higher fungi and identifying the key enzymes involved in its biosynthetic pathway. After understanding the biochemical and genetic basis for these natural products biosynthesis, then we use this information to improve the production and to develop novel therapeutically relevant compounds.
Expanding the chemical diversity of natural products by combination chemical synthesis and biosynthesis
Natural products and their derivatives have played a prominent role in the history of drug discovery and remain the most attractive source of potential drugs because of their structural complexity and diversity. However, construction of complex natural products and the development of large collections of biologically relevant molecules present significant challenges to synthetic chemists. To do this, we developed a strategy combined biosynthesis and chemical synthesis to expanding the chemical diversity of natural products.
· Publications
1.Construction of a meroterpenoid-like compound collection by precursor-assisted biosynthesis. Panlong Ren, Xinyu Miao, Ting Tang, Yueting Wu, Jing Wang, Ying Zeng, Yun Li, Kun Gao *, Yanlong Yang*. Org. Biomol. Chem. 2020, 18, 5850-5856.
2. Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining. Xinlin Li#, Yuxing Xu#, Yuan Li, RuiZhang, Tianyuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yanlong Yang*, Wei Gao*. Fungal. Genet. Biol. 2019, 128, 36-42.
3. Clavipines A–C, antiproliferative meroterpenoids with a fused azepine skeleton from the basidiomycete Clitocybe clavipes. Zhaocui Sun, Nailiang Zhu, Man Zhou, Xiaowei Huo, Haifeng Wu, Yu Tian, Junshan Yang, Guoxu Ma*, Yanlong Yang*, and Xudong Xu*. Org. Chem. Front. 2019, 6, 3759-3765.
4. Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis. Yanlong Yang, Yuting Zhang, Shasha Zhang, Qingwen Chen, Ke Ma, Li Bao, Yong Tao, Wenbing Yin, Guodong Wang, and Hongwei Liu. J. Nat. Prod. 2018, 81, 1089-1092.
5. Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Yanlong Yang，Shasha Zhang，Ke Ma，Yuxing Xu，Qiaoqiao Tao，Yihua Chen，Juan Chen， Shunxing Guo，Jinwei Ren，Wenzhao Wang，Yong Tao，Wenbing Yin, and Hongwei Liu*. Angew. Chem. Int. Ed. 2017, 56, 4749-4752.
6. Recent Advance on Bioactive Compounds from the Edible and Medicinal Fungi in China. Yanlong Yang, Qiaoqiao Tao, Junjie Han, Li Bao, and Hongwei Liu*. 2017, Medicinal Plants and Fungi: Recent Advances in Research and Development pp 253-312.
7. A monooxygenase from Boreostereum vibrans catalyzes oxidative decarboxylation in a divergent vibralactone biosynthesis pathway. Yanlong Yang, Hui Zhou, Gang Du, Kena Feng, Tao Feng, Xiaoli Fu, Jikai Liu*, and Ying Zeng*. Angew. Chem. Int. Ed. 2016, 55, 5463-5466.
8. Bioactive Sesquiterpenes from the Edible Mushroom Flammulina velutipes and Their Biosynthetic Pathway Confirmed by Genome Analysis and Chemical Evidence. Qiaoqiao Tao#, Ke Ma#, Yanlong Yang#, Kai Wang, Baosong Chen, Ying Huang, Junjie Han, Li Bao, Xiaobin Liu, Zhuliang Yang, Wenbing Yin, and Hongwei Liu*. J. Org. Chem. 2016, 81, 9867-9877. (#co-first author)
9. Elucidating the biosynthetic pathway for vibralactone, a novel pancreatic lipase inhibitor with a fused bicyclic β-lactone. Peiji Zhao*, Yanlong Yang, Liangchen Du, Jikai Liu, and Ying Zeng*. Angew. Chem. Int. Ed. 2013, 52, 2298-2302.
